Nanomedicine for the Treatment of Alzheimer's Disease

被引：42

作者：

Formicola, Beatrice ^{[1
]}

Cox, Alysia ^{[1
]}

dal Magro, Roberta ^{[1
]}

Masserini, Massimo ^{[1
]}

Re, Francesca ^{[1
]}

机构：

[1] Univ Milano Bicocca, Sch Med & Surg, Nanomed Ctr NANOMIB, I-20854 Vedano Al Lambro, MB, Italy

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2019年 / 15卷 / 10期

关键词：

Nanoparticles; Alzheimer Disease; Beta-Amyloid; Beta-Secretase; Gamma-Secretase; Nanomedicine; Brain; Blood-Brain Barrier; BLOOD-BRAIN-BARRIER; AMYLOID-BETA OLIGOMERS; IRON-OXIDE NANOPARTICLES; GOLD NANOPARTICLES; DRUG-DELIVERY; SILICA NANOPARTICLES; THERAPEUTIC APPROACH; GROWTH-FACTOR; IN-VITRO; MULTIFUNCTIONAL NANOPARTICLES;

D O I：

10.1166/jbn.2019.2837

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Alzheimer's disease affects millions of people worldwide and this figure is continuously increasing. Currently, there is no resolutive cure for this disorder, but a valid contribution could be provided by nanomedicine, utilizing multi-functionalized nanodevices as drug vehicles with additional features of specific brain targeting. Nanomedicine may represent also a practicable strategy for the pharmaceutical industry that moved from small MW pharmaceuticals to larger biologicals, such as antibodies and nucleotides, as the next generation of drugs, leading to the challenge of effective drug delivery. This review provides a survey on the nano-based strategies for Alzheimer's disease diagnosis and treatment, aiming at enhancing the passage of candidate pharmaceuticals across the BBB, and at supporting the evaluation of new therapeutic agents targeting this disease.

引用

页码：1997 / 2024

页数：28

共 223 条

[1] Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake [J].

Abels, Erik R. ;

Breakefield, Xandra O. .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2016, 36 (03) :301-312

[2]

Abu Lila AS, 2017, BIOL PHARM BULL, V40, P1, DOI 10.1248/bpb.b16-00624

[3] Liposome: classification, preparation, and applications [J].

Akbarzadeh, Abolfazl ;

Rezaei-Sadabady, Rogaie ;

Davaran, Soodabeh ;

Joo, Sang Woo ;

Zarghami, Nosratollah ;

Hanifehpour, Younes ;

Samiei, Mohammad ;

Kouhi, Mohammad ;

Nejati-Koshki, Kazem .

NANOSCALE RESEARCH LETTERS, 2013, 8

[4] In Vivo Distribution and Toxicity of PAMAM Dendrimers in the Central Nervous System Depend on Their Surface Chemistry [J].

Albertazzi, Lorenzo ;

Gherardini, Lisa ;

Brondi, Marco ;

Sato, Sebastian Sulis ;

Bifone, Angelo ;

Pizzorusso, Tommaso ;

Ratto, Gian Michele ;

Bardi, Giuseppe .

MOLECULAR PHARMACEUTICS, 2013, 10 (01) :249-260

[5] Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an Aβ1-42 Mouse Model of Alzheimer's Disease [J].

Ali, Tahir ;

Kim, Min Ju ;

Rehman, Shafiq Ur ;

Ahmad, Ashfaq ;

Kim, Myeong Ok .

MOLECULAR NEUROBIOLOGY, 2017, 54 (08) :6490-6506

[6] Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus [J].

Ali, Tahir ;

Yoon, Gwang Ho ;

Shah, Shahid Ali ;

Lee, Hae Young ;

Kim, Myeong Ok .

SCIENTIFIC REPORTS, 2015, 5

[7] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[8] NATURAL ANTIBODIES AGAINST PHOSPHOLIPIDS AND LIPOSOMES IN HUMANS [J].

ALVING, CR .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1984, 12 (02) :342-344

[9] Pericytes and the blood-brain barrier: recent advances and implications for the delivery of CNS therapy [J].

Armulik, Annika ;

Mae, Maarja ;

Betsholtz, Christer .

THERAPEUTIC DELIVERY, 2011, 2 (04) :419-422

[10] The manganese health research program (MHRP): Status report and future research needs and directions [J].

Aschner, M. ;

Lukey, B. ;

Tremblay, A. .

NEUROTOXICOLOGY, 2006, 27 (05) :733-736

← 1 2 3 4 5 6 7 8 9 10 →