Post-translational modifications of Runx1 regulate its activity in the cell

被引：28
作者：
Wang, Lan [1 ]
Huang, Gang [1 ]
Zhao, Xinyang [1 ]
Hatlen, Megan A. [1 ]
Vu, Ly [1 ]
Liu, Fan [1 ]
Nimer, Stephen D. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10065 USA
来源：
BLOOD CELLS MOLECULES AND DISEASES | 2009年 / 43卷 / 01期
关键词：
Methyltransferases; Acetyltransferases; Leukemia; Transcription; Methylation; Acetylation; CREB-BINDING-PROTEIN; FUSION PROTEIN; HEMATOPOIETIC STEM; GENE-EXPRESSION; ACUTE-LEUKEMIA; FACTORS AML1; PHOSPHORYLATION; TRANSCRIPTION; P300; DIFFERENTIATION;
D O I：
10.1016/j.bcmd.2009.03.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modi. cation can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：30 / 34
页数：5
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