Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action (Review)

被引：14

作者：

Styshova, Olga Nikolaevna ^{[1
]}

Popov, Alexander Michailovich ^{[1
,2
]}

Artyukov, Alexander Alekseevish ^{[1
]}

Klimovich, Anna Anatolievna ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Pr-t 100 let Vladivostoku 159, Vladivostok 690022, Russia

[2] Far Eastern Fed Univ, Sch Nat Sci, Vladivostok 690000, Russia

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2017年 / 13卷 / 05期

关键词：

metabolic syndrome; diabetes; hyperlipidemia; flavonoids; luteolin; rosmarinic acid; DIFFERENT MODEL SYSTEMS; ROSMARINIC ACID; GAMMA ACTIVATION; SEA HYDROBIONTS; IN-SITU; LUTEOLIN; CELLS; ANTIOXIDANTS; APOPTOSIS; RECEPTOR;

D O I：

10.3892/etm.2017.4217

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present review analyzed the recent experimental studies of the alleviating activity of main constituents of the polyphenol complex from seagrasses of the genus Zostera, namely rosmarinic acid, luteolin and its sulfated derivatives, on carbohydrate and lipid metabolism disorders. A number of studies by our group and others, in which various experimental models of diabetes and hyperlipidemia were used, show a therapeutic action of the polyphenol complex and the abovementioned phenolic constituents, when applied separately and in combination. Based on the analysis of the results of these studies, the probable mechanisms of the therapeutic action of these compounds in diabetes and hyperlipidemia were proposed.

引用

页码：1651 / 1659

页数：9

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