Wip1-deficient mice are resistant to common cancer genes

被引：54

作者：

Harrison, M

Li, J

Degenhardt, Y

Hoey, T

Powers, S

机构：

[1] Tularik Ltd, Macclesfield SK19 2XR, Cheshire, England

[2] Tularik Inc, Genom Div, Greenlawn, NY 11740 USA

[3] Tularik Inc, San Francisco, CA 94080 USA

[4] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 08期

关键词：

D O I：

10.1016/j.molmed.2004.06.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PPM1D encodes WIP1, a serine-threonine phosphatase that had previously been shown to be the driver oncogene of a 17q23 amplicon that is present in similar to15% of human breast tumors. However, it is unknown whether it has any role in the remaining 85% of breast tumors. A recent study using Wip1-deficient mice revealed that blocking its function significantly impaired RAS and ERBB2-induced breast tumor formation, suggesting that the inhibition of Wip1 could be a broad-spectrum treatment for breast cancer. However, because of the structure of Wip1, the development of small molecule inhibitors is a significant challenge.

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页码：359 / 361

页数：3

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