Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC

被引：937

作者：

Caraceni, Augusto ^{[1
,3
]}

Hanks, Geoff Rey ^{[2
]}

Kaasa, Stein ^{[3
,6
]}

Bennett, Michael I. ^{[8
]}

Brunelli, Cinzia

Cherny, Nathan ^{[9
]}

Dale, Ola ^{[4
]}

De Conno, Franco ^{[10
]}

Fallon, Marie ^{[11
]}

Hanna, Magdi ^{[12
]}

Haugen, Dagny Faksvag ^{[5
,13
]}

Juhl, Gitte ^{[14
]}

King, Samuel ^{[2
]}

Klepstad, Pal ^{[4
,7
]}

Laugsand, Eivor A. ^{[3
]}

Maltoni, Marco ^{[15
]}

Mercadante, Sebastiano ^{[16
,17
]}

Nabal, Maria ^{[18
]}

Pigni, Alessandra

Radbruch, Lukas ^{[19
]}

Reid, Colette ^{[2
]}

Sjogren, Per ^{[20
]}

Stone, Patrick C. ^{[21
]}

Tassinari, Davide ^{[22
]}

Zeppetella, Giovambattista ^{[23
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Palliat Care Pain Therapy & Rehabil Unit, I-20133 Milan, Italy

[2] Univ Bristol, Bristol Haematol & Oncol Ctr, Dept Palliat Med, Bristol, Avon, England

[3] Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Fac Med, Trondheim, Norway

[4] Norwegian Univ Sci & Technol NTNU, European Palliat Care Res Ctr PRC, Dept Circulat & Med Imaging, Trondheim, Norway

[5] Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Trondheim, Norway

[6] St Olavs Univ Hosp, Dept Oncol, Trondheim, Norway

[7] St Olavs Univ Hosp, Dept Anesthesiol & Emergency Med, Trondheim, Norway

[8] Univ Leeds, Leeds Inst Hlth Sci, Leeds, W Yorkshire, England

[9] Shaare Zedek Med Ctr, Dept Oncol, Jerusalem, Israel

[10] European Assoc Palliat Care, Milan, Italy

[11] Univ Edinburgh, St Columbias Hosp, Edinburgh, Midlothian, Scotland

[12] Kings Coll London, Analges & Pain Res Unit, London WC2R 2LS, England

[13] Haukeland Hosp, Reg Ctr Excellence Palliat Care, N-5021 Bergen, Norway

[14] Copenhagen Univ Hosp Herlev, Dept Anaesthesia, Palliat Care Unit, Herlev, Denmark

[15] Ist Sci Romagnolo Studio Cura Tumori, Dept Med Oncol, Meldola, Italy

[16] La Maddalena Canc Ctr, Pain Relief & Palliat Care Unit, Anaesthesia & Intens Care Unit, Palermo, Italy

[17] Univ Palermo, Dept Anaesthesia & Intens Care, Palermo, Italy

[18] Hosp Arnau Vilanova, Palliat Care Support Team, Lleida, Spain

[19] Univ Hosp Bonn, Dept Palliat Med, Bonn, Germany

[20] Copenhagen Univ Hosp, Rigshosp, Ctr Multidisciplinary Pain, Copenhagen, Denmark

[21] St Georges Univ London, London, England

[22] City Hosp, Dept Oncol, Support & Palliat Care Unit, Rimini, Italy

[23] St Clare Hosp, Patient Serv, Hastingwood, England

来源：

LANCET ONCOLOGY | 2012年 / 13卷 / 02期

关键词：

PATIENT-CONTROLLED ANALGESIA; CONTINUOUS SUBCUTANEOUS INFUSION; INTRANASAL FENTANYL SPRAY; RELEASE ORAL MORPHINE; PALLIATIVE CARE; BREAKTHROUGH PAIN; DOUBLE-BLIND; INTRAVENOUS MORPHINE; TRANSDERMAL FENTANYL; OPEN-LABEL;

D O I：

10.1016/S1470-2045(12)70040-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Here we provide the updated version of the guidelines of the European Association for Palliative Care ( EAPC) on the use of opioids for the treatment of cancer pain. The update was undertaken by the European Palliative Care Research Collaborative. Previous EAPC guidelines were reviewed and compared with other currently available guidelines, and consensus recommendations were created by formal international expert panel. The content of the guidelines was defined according to several topics, each of which was assigned to collaborators who developed systematic literature reviews with a common methodology. The recommendations were developed by a writing committee that combined the evidence derived from the systematic reviews with the panellists' evaluations in a co-authored process, and were endorsed by the EAPC Board of Directors. The guidelines are presented as a list of 16 evidence-based recommendations developed according to the Grading of Recommendations Assessment, Development and Evaluation system.

引用

页码：E58 / E68

页数：11

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