Iron(0)-Mediated Henry-Type Reaction of Bromonitromethane with Aldehydes for the Efficient Synthesis of 2-Nitro-alkan-1-ols

被引：4
|
作者：
Zhang Sixuan [1 ]
Li Xiangrui [1 ]
Li Wenxin [1 ]
Rao Weidong [2 ]
Ge Danhua [1 ]
Shen Zhiliang [1 ]
Chu Xueqiang [1 ]
机构：
[1] Nanjing Tech Univ, Chem Expt Teaching Ctr, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China
[2] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Key Lab Biomass Based Green Fuels & Chem, Nanjing 21003, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 01期
基金：
中国国家自然科学基金;
关键词：
iron; lead dichloride; Henry-type reaction; bromonitromethane; 2-nitro-alkan-1-ol; SELECTIVE REDUCTION; DIRECT INSERTION; AMINO-ALCOHOLS; IRON; NITROARENES; CATALYSIS; ALUMINUM; ALLYLATION; KETONES; AMIDES;
D O I：
10.6023/cjoc202107048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Henry-type reaction of bromonitromethane with various aldehydes for the efficient synthesis of 2-nitro-alkan-ols by using inexpensive and commercial iron powder as reaction mediator was developed. The reaction proceeded efficiently in the presence of PbCl2 and tetrabutylammonium hydrogen sulfate (TBAHS) to produce the desired products in moderate to good yield with wide functional group tolerance.
引用
收藏
页码：235 / 241
页数：7
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