The potential applications of ZnO nanoparticles conjugated with ALA and photofrin as a biomarker in HepG2 cells

被引：17

作者：

Fakhar-e-Alam, M. ^{[1
]}

Firdous, S. ^{[2
]}

Atif, M. ^{[2
,3
]}

Khan, Y. ^{[1
]}

Zaidi, S. S. Z. ^{[4
]}

Suleman, R. ^{[4
]}

Rehman, A. ^{[2
]}

Khan, R. U. ^{[1
]}

Nawaz, M. ^{[2
]}

Ikram, M. ^{[1
]}

机构：

[1] Pakistan Inst Engn & Appl Sci, Islamabad 45650, Pakistan

[2] Natl Inst Laser & Optron, Islamabad 45650, Pakistan

[3] King Saud Univ, Coll Sci, Dept Phys & Astron, Res Chair Laser Diag Canc, Riyadh 11451, Saudi Arabia

[4] Natl Inst Hlth, Islamabad, Pakistan

来源：

LASER PHYSICS | 2011年 / 21卷 / 12期

关键词：

PHOTODYNAMIC THERAPY; IN-VITRO; OPTICAL-PROPERTIES; QUANTUM DOTS; FLUORESCENCE; NANOCOMPOSITES; VIABILITY;

D O I：

10.1134/S1054660X11210067

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Drug delivery into the malignant cell is a basic requirement for effectiveness of photosensitizing systems for photodynamic therapy (PDT). For anticancer tumoricidal drugs, e.g., 5-aminolevulinic acid (ALA), zinc oxide (ZnO) nanoparticles (NPs) are used as efficient intracellular photosensitizer carriers. Apoptotic effect of tumoricidal drugs (ALA and Photofrin cells in the presence and absence of ZnO NPs using confocal microscopy as well as Neutral Red Assay (NRA). In dark, ZnO NPs conjugated with ALA or Photofrinhas been found to have a remarkable fluorescence in Hepatucellular carcinoma (HepG2) cells. This fact illustrates the great potential of ZnO NPs as biomarker in relevant clinical and biomedical applications.

引用

页码：2156 / 2164

页数：9

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