Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

被引：124
|
作者：
Liang, Guang [1 ,2 ]
Li, Xiaokun [1 ,3 ,4 ]
Chen, Li [2 ]
Yang, Shulin [3 ]
Wu, Xudong [2 ]
Studer, Elaine [2 ]
Gurley, Emily [2 ]
Hylemon, Phillip B. [2 ]
Ye, Faqing [1 ]
Li, Yueru [4 ]
Zhou, Huiping [1 ,2 ]
机构：
[1] Wenzhou Med Coll, Coll Pharm, Wenzhou 325035, Peoples R China
[2] Virginia Commonwealth Univ, Sch Med, Dept Microbiol & Immunol, Richmond, VA 23298 USA
[3] Nanjing Univ Sci& Technol, Coll Chem, Nanjing 210049, Peoples R China
[4] Jilin Agr Univ, Minist Educ, Engn Res Ctr Bioreactor & Pharmaceut Dev, Changchun 130118, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期
关键词：
curcumin; anti-inflammation; TNF-alpha; IL-6;
D O I：
10.1016/j.bmcl.2007.12.068
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The beta-diketone moiety renders curcumin to be rapidly metabolized by aldo -keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide ( LPS)-induced TNF-alpha and IL-6 synthesis in macrophages. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1525 / 1529
页数：5
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