A new bioactive compound from the roots of Petasites hybridus

被引：37

作者：

Khaleghi, Fatemeh ^{[2
]}

Bin Din, Laily ^{[2
]}

Charati, Faramarz Rostami ^{[3
]}

Yaacob, Wan Ahmad ^{[2
]}

Khalilzadeh, Mohammad A. ^{[1
]}

Skelton, Brian ^{[4
]}

Makha, Mohamed ^{[4
]}

机构：

[1] Islamic Azad Univ, Qaemshahr Branch, Dept Chem, Qaemshahr, Iran

[2] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Chem Sci & Food Technol, Bangi 43600, Selangor, Malaysia

[3] Gonbad Higher Educ Ctr, Gonbad, Iran

[4] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Perth, WA 6009, Australia

来源：

PHYTOCHEMISTRY LETTERS | 2011年 / 4卷 / 03期

关键词：

Petasites hybridus; Benzofuran derivatie; Bovine serum albumin (BSA); Human breast cancer MCF-7; DNA; DNA-DAMAGE; EXTRACT;

D O I：

10.1016/j.phytol.2011.04.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：254 / 258

页数：5

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