The future of fluorescence sensor arrays

被引：43
作者：
Demchenko, AP [1 ]
机构：
[1] TUBITAK Res Inst Genet Engn & Biotechnol, TR-41470 Gebze, Kocaeli, Turkey
[2] Univ Louis Pasteur Strasbourg 1, Fac Pharm, UMR 7034, F-67401 Illkirch Graffenstaden, France
来源：
TRENDS IN BIOTECHNOLOGY | 2005年 / 23卷 / 09期
关键词：
D O I：
10.1016/j.tibtech.2005.06.003
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The rapid progress in sensor and biosensor array technologies needs a general strategy in the design of fluorescence reporters. Such reporters should provide a high density of sensor elements, allow analysis of targets of different affinities, and be internally calibrated, reproducible and have a rapid readout. Several criteria are introduced here for the comparative evaluation of fluorescence-sensing techniques. It is shown that only the two-band wavelength ratiometric sensing with a single reporter dye exhibiting rapid reversible excited-state reaction can satisfy all these criteria and is a prospective candidate for further development.
引用
收藏
页码：456 / 460
页数：5
相关论文
共 26 条
[1]   Flavonols - new fluorescent membrane probes for studying the interdigitation of lipid bilayers [J].
Bondar, OP ;
Pivovarenko, VG ;
Rowe, ES .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1998, 1369 (01) :119-130
[2]   Construction of a fluorescent biosensor family [J].
De Lorimier, RM ;
Smith, JJ ;
Dwyer, MA ;
Looger, LL ;
Sali, KM ;
Paavola, CD ;
Rizk, SS ;
Sadigov, S ;
Conrad, DW ;
Loew, L ;
Hellinga, HW .
PROTEIN SCIENCE, 2002, 11 (11) :2655-2675
[3]   Signaling recognition events with fluorescent sensors and switches [J].
de Silva, AP ;
Gunaratne, HQN ;
Gunnlaugsson, T ;
Huxley, AJM ;
McCoy, CP ;
Rademacher, JT ;
Rice, TE .
CHEMICAL REVIEWS, 1997, 97 (05) :1515-1566
[4]   Optimization of fluorescence response in the design of molecular biosensors [J].
Demchenko, AP .
ANALYTICAL BIOCHEMISTRY, 2005, 343 (01) :1-22
[5]   Multiparametric color-changing fluorescence probes [J].
Demchenko, AP ;
Klymchenko, AS ;
Pivovarenko, VG ;
Ercelen, S ;
Duportail, G ;
Mely, Y .
JOURNAL OF FLUORESCENCE, 2003, 13 (04) :291-295
[6]   Neutral fluorescence probe with strong ratiometric response to surface charge of phospholipid membranes [J].
Duportail, G ;
Klymchenko, A ;
Mely, Y ;
Demchenko, A .
FEBS LETTERS, 2001, 508 (02) :196-200
[7]   On the coupling between surface charge and hydration in biomembranes:: Experiments with 3-hydroxyflavone probes [J].
Duportail, G ;
Klymchenko, A ;
Mély, Y ;
Demchenko, AP .
JOURNAL OF FLUORESCENCE, 2002, 12 (02) :181-185
[8]   Ultrasensitive fluorescent probe for the hydrophobic range of solvent polarities [J].
Ercelen, S ;
Klymchenko, AS ;
Demchenko, AP .
ANALYTICA CHIMICA ACTA, 2002, 464 (02) :273-287
[9]   Fluorescent-protein biosensors: new tools for drug discovery [J].
Giuliano, KA ;
Taylor, DL .
TRENDS IN BIOTECHNOLOGY, 1998, 16 (03) :135-140
[10]   Protein engineering and the development of generic biosensors [J].
Hellinga, HW ;
Marvin, JS .
TRENDS IN BIOTECHNOLOGY, 1998, 16 (04) :183-189
123