Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review

被引：79

作者：

Garcia-Foncillas, J. ^{[1
]}

Alba, E. ^{[2
]}

Aranda, E. ^{[3
]}

Diaz-Rubio, E. ^{[4
]}

Lopez-Lopez, R. ^{[5
,6
,7
]}

Tabernero, J. ^{[8
,9
]}

Vivancos, A. ^{[10
]}

机构：

[1] Autonomous Univ, Fdn Jimenez Diaz, Univ Hosp, Inst Canc, Madrid, Spain

[2] Reg Univ Hosp Virgen de la Victoria, Med Oncol Unit, IBIMA, Malaga, Spain

[3] Univ Cordoba, Fac Med, Hosp Reina Sofia, Biomed Res Inst IMIBIC,CIBERONC, Cordoba, Spain

[4] Univ Complutense Madrid, Fac Med, Hosp Clin San Carlos, Res Inst IdISSC,CIBERONC, Madrid, Spain

[5] Univ Clin Hosp, Dept Med Oncol, Santiago De Compostela, Spain

[6] Univ Clin Hosp, Hlth Res Inst IDIS, Santiago De Compostela, Spain

[7] Santiago de Compostela Univ, Sch Med, CIBERONC, Santiago De Compostela, Spain

[8] Vall dHebron Univ Hosp, Med Oncol, Barcelona, Spain

[9] Univ Autonoma Barcelona, Inst Oncol VHIO, CIBERONC, Barcelona, Spain

[10] Vall dHebron Inst Oncol VHIO, Canc Genom Lab, Barcelona, Spain

来源：

ANNALS OF ONCOLOGY | 2017年 / 28卷 / 12期

关键词：

colorectal cancer; mutation testing; liquid biopsy; EGFR; tumor resistance; CIRCULATING TUMOR DNA; ANTI-EGFR THERAPY; PLUS CETUXIMAB TREATMENT; RAS MUTATIONS; ACQUIRED-RESISTANCE; 1ST-LINE TREATMENT; TARGETED THERAPY; MUTANT-DNA; PLASMA; FOLFIRI;

D O I：

10.1093/annonc/mdx501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/ or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.

引用

页码：2943 / 2949

页数：7

共 45 条

[11] Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients [J].

Diehl, Frank ;

Schmidt, Kerstin ;

Durkee, Kristine H. ;

Moore, Kent J. ;

Goodman, Steve N. ;

Shuber, Anthony P. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert .

GASTROENTEROLOGY, 2008, 135 (02) :489-498

[12] Panitumumab-FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer [J].

Douillard, Jean-Yves ;

Oliner, Kelly S. ;

Siena, Salvatore ;

Tabernero, Josep ;

Burkes, Ronald ;

Barugel, Mario ;

Humblet, Yves ;

Bodoky, Gyorgy ;

Cunningham, David ;

Jassem, Jacek ;

Rivera, Fernando ;

Kocakova, Ilona ;

Ruff, Paul ;

Blasinska-Morawiec, Maria ;

Smakal, Martin ;

Canon, Jean Luc ;

Rother, Mark ;

Williams, Richard ;

Rong, Alan ;

Wiezorek, Jeffrey ;

Sidhu, Roger ;

Patterson, Scott D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (11) :1023-1034

[13] Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer [J].

Grasselli, J. ;

Elez, E. ;

Caratu, G. ;

Matito, J. ;

Santos, C. ;

Macarulla, T. ;

Vidal, J. ;

Garcia, M. ;

Vieitez, J. M. ;

Paez, D. ;

Falco, E. ;

Lopez Lopez, C. ;

Aranda, E. ;

Jones, F. ;

Sikri, V. ;

Nuciforo, P. ;

Fasani, R. ;

Tabernero, J. ;

Montagut, C. ;

Azuara, D. ;

Dienstmann, R. ;

Salazar, R. ;

Vivancos, A. .

ANNALS OF ONCOLOGY, 2017, 28 (06) :1294-1301

[14] Clinical performance comparison of RAS mutation detection in plasma and tissue samples from stage IV colorectal cancer patients for first-line anti-EGFR therapy selection [J].

Hahn, S. ;

Tannapfel, A. ;

Friess, H. ;

Janssen, K. P. ;

Nitsche, U. ;

Slotta-Huspenina, J. ;

Pohl, M. ;

Vangala, D. B. ;

Jones, F. S. ;

Dockhorn-Dworniczak, B. ;

Hegewisch-Becker, S. ;

Schmiegel, W. .

EUROPEAN JOURNAL OF CANCER, 2015, 51 :S79-S79

[15] FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial [J].

Heinemann, Volker ;

von Weikersthal, Ludwig Fischer ;

Decker, Thomas ;

Kiani, Alexander ;

Vehling-Kaiser, Ursula ;

Al-Batran, Salah-Eddin ;

Heintges, Tobias ;

Lerchenmueller, Christian ;

Kahl, Christoph ;

Seipelt, Gernot ;

Kullmann, Frank ;

Stauch, Martina ;

Scheithauer, Werner ;

Hielscher, Joerg ;

Scholz, Michael ;

Mueller, Sebastian ;

Link, Hartmut ;

Niederle, Norbert ;

Rost, Andreas ;

Hoeffkes, Heinz-Gert ;

Moehler, Markus ;

Lindig, Reinhard U. ;

Modest, Dominik P. ;

Rossius, Lisa ;

Kirchner, Thomas ;

Jung, Andreas ;

Stintzing, Sebastian .

LANCET ONCOLOGY, 2014, 15 (10) :1065-1075

[16] Pathologists and liquid biopsies: to be or not to be? [J].

Hofman, Paul ;

Popper, Helmut H. .

VIRCHOWS ARCHIV, 2016, 469 (06) :601-609

[17] Mutant DNA in plasma of lung cancer patients - Potential for monitoring response to therapy [J].

Kimura, T ;

Holland, WS ;

Kawaguchi, T ;

Williamson, SK ;

Chansky, K ;

Crowley, JJ ;

Doroshow, JH ;

Lenz, HJ ;

Gandara, DR ;

Gumerlock, PH .

CIRCULATING NUCLEIC ACIDS IN PLASMA/SERUM III AND SERUM PROTEOMICS, 2004, 1022 :55-60

[18] Mutation and copy number discordance in primary versus metastatic colorectal cancer (mCRC). [J].

Kopetz, Scott ;

Overman, Michael J. ;

Chen, Ken ;

Lucio-Eterovic, Agda Karina ;

Kee, Bryan K. ;

Fogelman, David R. ;

Dasari, Arvind ;

Pratap, Kanwal ;

Raghav, Singh ;

Sanchez, Eduardo Vilar ;

Phillips, Jonathan ;

Shureiqi, Imad ;

Garrett, Chris R. ;

Wolff, Robert A. ;

Patel, Keyur ;

Aldape, Kenneth D. ;

Luthra, Rajyalakshmi ;

Routbort, Mark ;

Maru, Dipen M. ;

Meric-Bernstam, Funda ;

Eng, Cathy .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)

[19] Metastatic colorectal cancer KRAS genotyping in routine practice: results and pitfalls [J].

Lamy, Aude ;

Blanchard, France ;

Le Pessot, Florence ;

Sesbouee, Richard ;

Di Fiore, Frederic ;

Bossut, Jessie ;

Fiant, Elodie ;

Frebourg, Thierry ;

Sabourin, Jean-Christophe .

MODERN PATHOLOGY, 2011, 24 (08) :1090-1100

[20] BEAMing up for detection and quantification of rare sequence variants [J].

Li, M ;

Diehl, F ;

Dressman, D ;

Vogelstein, B ;

Kinzler, KW .

NATURE METHODS, 2006, 3 (02) :95-97

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