Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review

被引：79

作者：

Garcia-Foncillas, J. ^{[1
]}

Alba, E. ^{[2
]}

Aranda, E. ^{[3
]}

Diaz-Rubio, E. ^{[4
]}

Lopez-Lopez, R. ^{[5
,6
,7
]}

Tabernero, J. ^{[8
,9
]}

Vivancos, A. ^{[10
]}

机构：

[1] Autonomous Univ, Fdn Jimenez Diaz, Univ Hosp, Inst Canc, Madrid, Spain

[2] Reg Univ Hosp Virgen de la Victoria, Med Oncol Unit, IBIMA, Malaga, Spain

[3] Univ Cordoba, Fac Med, Hosp Reina Sofia, Biomed Res Inst IMIBIC,CIBERONC, Cordoba, Spain

[4] Univ Complutense Madrid, Fac Med, Hosp Clin San Carlos, Res Inst IdISSC,CIBERONC, Madrid, Spain

[5] Univ Clin Hosp, Dept Med Oncol, Santiago De Compostela, Spain

[6] Univ Clin Hosp, Hlth Res Inst IDIS, Santiago De Compostela, Spain

[7] Santiago de Compostela Univ, Sch Med, CIBERONC, Santiago De Compostela, Spain

[8] Vall dHebron Univ Hosp, Med Oncol, Barcelona, Spain

[9] Univ Autonoma Barcelona, Inst Oncol VHIO, CIBERONC, Barcelona, Spain

[10] Vall dHebron Inst Oncol VHIO, Canc Genom Lab, Barcelona, Spain

来源：

ANNALS OF ONCOLOGY | 2017年 / 28卷 / 12期

关键词：

colorectal cancer; mutation testing; liquid biopsy; EGFR; tumor resistance; CIRCULATING TUMOR DNA; ANTI-EGFR THERAPY; PLUS CETUXIMAB TREATMENT; RAS MUTATIONS; ACQUIRED-RESISTANCE; 1ST-LINE TREATMENT; TARGETED THERAPY; MUTANT-DNA; PLASMA; FOLFIRI;

D O I：

10.1093/annonc/mdx501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/ or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.

引用

页码：2943 / 2949

页数：7

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