Contemporary Evaluation and Management of Upper Tract Urothelial Cancer

被引：9

作者：

Mandalapu, Rao S. ^{[1
]}

Matin, Surena F. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

来源：

UROLOGY | 2016年 / 94卷

关键词：

UPPER URINARY-TRACT; TRANSITIONAL-CELL CARCINOMA; RENAL PELVIS; NEOADJUVANT CHEMOTHERAPY; RADICAL NEPHROURETERECTOMY; ENDOSCOPIC MANAGEMENT; MITOMYCIN-C; PHASE-II; ADJUVANT; URETER;

D O I：

10.1016/j.urology.2015.12.035

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Radical nephroureterectomy with en bloc bladder cuff excision and regional lymphadenectomy is the gold standard for the management of high-grade and high-risk upper tract urothelial carcinomas. There are a few prospective randomized controlled studies in this uncommon and often aggressive disease to support level-1 management guidelines. However, recent developments in imaging, minimally invasive techniques, lymphatic dissemination, and bladder cancer prevention raise the hope for improved risk stratification and treatments without compromising, and hopefully improving, oncological outcomes. Multimodality approaches in terms of neoadjuvant, adjuvant topical, and systemic chemotherapeutic regimens are promising, with 2 prospective trials either open or in development. (C) 2016 Elsevier Inc.

引用

页码：17 / 23

页数：7

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