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EXPRESSION OF IGF1, IGF1R, AND SP1 FACTORS IN HPV INFECTED CERVICAL CANCER CELLS
被引:0
|作者:
Koczorowska, Maria Magdalena
[1
]
Kwasniewska, Anna
[2
]
Gozdzicka-Jozefiak, Anna
[1
]
机构:
[1] Adam Mickiewicz Univ, Dept Mol Virol, PL-61614 Poznan, Poland
[2] Med Univ, Dept Obstet & Gynecol, PL-20081 Lublin, Poland
关键词:
IGF;
IGF1R;
SP1;
cervical cancer;
human papillomavirus;
GROWTH-FACTOR-I;
HUMAN-PAPILLOMAVIRUS TYPE-16;
INSULIN;
RECEPTOR;
WOMEN;
GENE;
INSULIN-LIKE-GROWTH-FACTOR-1;
PROTEINS;
REVERSE;
SYSTEM;
D O I:
暂无
中图分类号:
S85 [动物医学(兽医学)];
学科分类号:
0906 ;
摘要:
The aim of the study was to investigate the mRNA expression levels of IGF1, IGF1R, and SP1 in cervical epithelial cells in different stages of cervical cancerogenesis using real-time PCR. The analysis indicated up-regulation of IGF1 gene expression in L-SIL and H-SIL, followed by its down-regulation in cervical cancer. Firstly, the obtained results suggest that IGF1 can be recognised as an essential factor in cervical cancerogenesis; secondly the SP1 action may be crucial for IGF1 expression.
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页码:281 / 286
页数:6
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