EXPRESSION OF IGF1, IGF1R, AND SP1 FACTORS IN HPV INFECTED CERVICAL CANCER CELLS

被引：0
|
作者：
Koczorowska, Maria Magdalena [1 ]
Kwasniewska, Anna [2 ]
Gozdzicka-Jozefiak, Anna [1 ]
机构：
[1] Adam Mickiewicz Univ, Dept Mol Virol, PL-61614 Poznan, Poland
[2] Med Univ, Dept Obstet & Gynecol, PL-20081 Lublin, Poland
来源：
BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2011年 / 55卷 / 02期
关键词：
IGF; IGF1R; SP1; cervical cancer; human papillomavirus; GROWTH-FACTOR-I; HUMAN-PAPILLOMAVIRUS TYPE-16; INSULIN; RECEPTOR; WOMEN; GENE; INSULIN-LIKE-GROWTH-FACTOR-1; PROTEINS; REVERSE; SYSTEM;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The aim of the study was to investigate the mRNA expression levels of IGF1, IGF1R, and SP1 in cervical epithelial cells in different stages of cervical cancerogenesis using real-time PCR. The analysis indicated up-regulation of IGF1 gene expression in L-SIL and H-SIL, followed by its down-regulation in cervical cancer. Firstly, the obtained results suggest that IGF1 can be recognised as an essential factor in cervical cancerogenesis; secondly the SP1 action may be crucial for IGF1 expression.
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收藏
页码：281 / 286
页数：6
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