Studies of a furanoside as antimycobacterial agent loaded into a biodegradable PBAT/sodium caseinate support

被引：13

作者：

Legentil, Laurent ^{[1
]}

Audic, Jean-Luc

Daniellou, Richard

Nugier-Chauvin, Caroline

Ferrieres, Vincent

机构：

[1] Ecole Natl Super Chim Rennes, CNR, UMR 6226, F-35708 Rennes 7, France

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 12期

关键词：

SYNTHETIC UDP-FURANOSES; INHIBITORS; TRIAZOLES; GROWTH;

D O I：

10.1016/j.carres.2011.04.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An improved synthesis of n-octyl beta-D-galactofuranoside was described using micro-wave activation. The resulting alkyl furanoside showed antibacterial activity against Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis. It was further incorporated into a biodegradable PBAT/sodium caseinate polymer. The resulting biomaterial loaded with 5% of the pharmacophore retained the mycobacteriostatic properties and developed a mycobactericidal activity on contact and at the periphery of the film. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1541 / 1545

页数：5

共 30 条

[1] Functional polymethacrylates as bacteriostatic polymers [J].

Adelmann, Ronald ;

Mennicken, Martina ;

Popescu, Dragos ;

Heine, Elisabeth ;

Keul, Helmut ;

Moeller, Martin .

EUROPEAN POLYMER JOURNAL, 2009, 45 (11) :3093-3107

[2] Synthesis, physico-chemical properties and completing abilities of new amphiphilic ligands from D-galacturonic acid [J].

Allam, Anas ;

Behr, Jean-Bernard ;

Dupont, Laurent ;

Nardello-Rataj, Veronique ;

Plantier-Royon, Richard .

CARBOHYDRATE RESEARCH, 2010, 345 (06) :731-739

[3]

AUDIC JL, 2010, Patent No. 1002815

[4] TREATMENT OF TUBERCULOSIS AND TUBERCULOSIS INFECTION IN ADULTS AND CHILDREN [J].

BASS, JB ;

FARER, LS ;

HOPEWELL, PC ;

OBRIEN, R ;

JACOBS, RF ;

RUBEN, F ;

SNIDER, DE ;

THORNTON, G .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (05) :1359-1374

[5]

Brady RF, 2007, ACS SYM SER, V957, P3

[6]

Brochu Heidi, 2004, Current Drug Delivery, V1, P299, DOI 10.2174/1567201043334678

[7] Copper nanoparticle/polymer composites with antifungal and bacteriostatic properties [J].

Cioffi, N ;

Torsi, L ;

Ditaranto, N ;

Tantillo, G ;

Ghibelli, L ;

Sabbatini, L ;

Bleve-Zacheo, T ;

D'Alessio, M ;

Zambonin, PG ;

Traversa, E .

CHEMISTRY OF MATERIALS, 2005, 17 (21) :5255-5262

[8]

Clemans DL, 2007, ACS SYM SER, V957, P27

[9]

Cohen J, 2006, SCIENCE, V313, P1554

[10] Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria [J].

Davis, Chris B. ;

Hartnell, Regan D. ;

Madge, Paul D. ;

Owen, David J. ;

Thomson, Robin J. ;

Chong, Andrew K. J. ;

Coppel, Ross L. ;

von Itzstein, Mark .

CARBOHYDRATE RESEARCH, 2007, 342 (12-13) :1773-1780

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