Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

被引：119

作者：

Walton, E. ^{[1
,2
,3
]}

Hibar, D. P. ^{[4
]}

van Erp, T. G. M. ^{[5
]}

Potkin, S. G. ^{[5
]}

Roiz-Santianez, R. ^{[6
,7
]}

Crespo-Facorro, B. ^{[6
,7
]}

Suarez-Pinilla, P. ^{[6
,7
]}

van Haren, N. E. M. ^{[8
]}

de Zwarte, S. M. C. ^{[8
]}

Kahn, R. S. ^{[8
]}

Cahn, W. ^{[8
]}

Doan, N. T. ^{[9
]}

Jorgensen, K. N. ^{[9
,10
]}

Gurholt, T. P. ^{[9
]}

Agartz, I. ^{[9
,10
,11
]}

Andreassen, O. A. ^{[9
]}

Westlye, L. T. ^{[9
]}

Melle, I. ^{[9
]}

Berg, A. O. ^{[9
]}

Morch-Johnsen, L. ^{[9
,10
]}

Faerden, A. ^{[12
]}

Flyckt, L. ^{[13
]}

Fatouros-Bergman, H. ^{[13
]}

Jonsson, E. G. ^{[9
,11
]}

Hashimoto, R. ^{[14
,15
]}

Yamamori, H. ^{[15
]}

Fukunaga, M. ^{[16
]}

Jahanshad, N. ^{[4
]}

De Rossi, P. ^{[17
,18
,19
]}

Piras, F. ^{[18
,20
,21
]}

Banaj, N. ^{[18
]}

Spalletta, G. ^{[18
,22
]}

Gur, R. E.

Gur, R. C.

Wolf, D. H. ^{[23
]}

Satterthwaite, T. D.

Beard, L. M.

Sommer, I. E. ^{[8
]}

Koops, S. ^{[8
]}

Gruber, O. ^{[24
]}

Richter, A. ^{[24
]}

Kraemer, B. ^{[24
]}

Kelly, S. ^{[4
,25
]}

Donohoe, G. ^{[26
]}

McDonald, C. ^{[26
]}

Cannon, D. M. ^{[26
]}

Corvin, A. ^{[25
]}

Gill, M. ^{[25
]}

Di Giorgio, A. ^{[27
]}

Bertolino, A. ^{[28
]}

机构：

[1] Georgia State Univ, Dept Psychol, Atlanta, GA 30302 USA

[2] Tech Univ Dresden, Fac Med, Div Psychol & Social Med & Dev Neurosci, Fetscherstr 74, D-01307 Dresden, Germany

[3] Kings Coll London, Inst Psychol Psychiat & Neurosci, Dept Psychol, London SE5 8AF, England

[4] Univ Southern Calif, Mark & Mary Stevens Inst Neuroimaging & Informat, Imaging Genet Ctr, Marina Del Rey, CA USA

[5] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA

[6] Univ Cantabria IDIVAL, Univ Hosp Marques Valdecilla, Sch Med, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain

[7] Cibersam Ctr Invest Biomed Red Salud Mental, Avda Valdecilla S-N, Santander 39008, Spain

[8] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands

[9] Univ Oslo, Div Mental Hlth & Addict, KG Jebsen Ctr Psychosis Res, NORMENT, POB 4956 Nydalen, N-0424 Oslo, Norway

[10] Diakonhjemmet Hosp, Dept Psychiat Res, POB 85 Vinderen, N-0319 Oslo, Norway

[11] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden

[12] Oslo Univ Hosp, Div Mental Hlth & Addict, POB 4956 Nydalen, N-0424 Oslo, Norway

[13] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Norra Stationsgatan 69, S-11364 Stockholm, Sweden

[14] Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, D3 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[15] Osaka Univ, Grad Sch Med D3, Dept Psychiat, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[16] Natl Inst Physiol Sci, Div Cerebral Integrat, 38 Nishigonaka Myodaiji, Okazaki, Aichi 4448585, Japan

[17] Sapienza Univ, Sch Med & Psychol, Dept Neurosci Mental Hlth & Sensory Functi, NESMOS, Rome, Italy

[18] IRCCS, Santa Lucia Fdn, Dept Clin & Behav Neurol, I-00179 Rome, Italy

[19] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[20] Ctr Fermi Museo Storico Fis, Rome, Italy

[21] Ctr & Ric Enrico Fermi, Rome, Italy

[22] Baylor Coll Med, Dept Psychiat & Behav Sci, Beth K & Stuart C Yudofsky Div Neuropsychiat Me, Houston, TX USA

[23] Univ Penn, Brain Behav Lab, Philadelphia, PA 19104 USA

[24] Univ Med Ctr Gottingen, Ctr Translat Res Syst Neurosci & Psychiat, Dept Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany

[25] Trinity Coll Dublin, Dublin, Ireland

[26] Natl Univ Ireland Galway, Galway Neurosci Ctr, NCBES, Ctr Neuroimaging & Cognit Genom NICOG, Galway, Ireland

[27] IRCCS Casa Sollievo Sofferenza, Sect Psychiat & Psychol, I-71013 San Giovanni Rotondo, FG, Italy

[28] Univ Bari Aldo Moro, Psychiat Neurosci Grp, I-70124 Bari, Italy

[29] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland

[30] Mind Res Network, Albuquerque, NM 87106 USA

[31] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA

[32] Georgia State Univ, Dept Psychol, Atlanta, GA 30302 USA

[33] Georgia State Univ, Neurosci Inst, Atlanta, GA 30302 USA

来源：

PSYCHOLOGICAL MEDICINE | 2018年 / 48卷 / 01期

关键词：

Cortical thickness; ENIGMA; FreeSurfer; medial orbitofrontal cortex; MRI; negative symptoms; PANSS; SANS; schizophrenia; 1ST-EPISODE PSYCHOSIS PATIENTS; DECISION-MAKING; BRAIN STRUCTURE; ORBITOFRONTAL CORTEX; CEREBRAL-CORTEX; GRAY-MATTER; THICKNESS; REWARD; VOLUME; DYSFUNCTION;

D O I：

10.1017/S0033291717001283

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity. Methods. This study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized Scale for the Assessment of Negative Symptoms or Positive and Negative Syndrome Scale scores). Results. Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (beta(std) =-0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged. Conclusions. Using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.

引用

页码：82 / 94

页数：13

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