SYNTHESIS AND CYTOTOXICITY OF NOVEL 4′-O-DEMETHYLPODOPHYLLOTOXIN DERIVATIVES AS POTENTIAL ANTICANCER AGENTS

被引：1
作者：
Tian, Dan-li [1 ]
Chen, Hong [2 ]
Luo, Gang [2 ]
Liang, Chun-po [3 ]
机构：
[1] Tianjin First Cent Hosp, Tianjin 300192, Peoples R China
[2] Logist Univ Chinese Peoples Armed Police Forces, Tianjin 300309, Peoples R China
[3] Tianjin Med Univ Gen Hosp, Tianjin 300052, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 04期
基金：
中国国家自然科学基金;
关键词：
antitumor; 4 '-O-demethylpodophyllotoxin; synthesis; cytotoxicity; structure-activity relationship; indole; ANTITUMOR-ACTIVITY; PODOPHYLLOTOXIN; INHIBITORS; TUBULIN;
D O I：
10.1007/s10600-022-03757-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ten 4 beta-N-substituted derivatives of 4'-O-demethylpodophyllotoxin were designed by aldehydes reacting with 4'-O-demethylpodophyllotoxin. Their cytotoxicity against cancer cell lines (HeLa) was evaluated using the MTT assay. Compounds 7a-7d, 7f, 7g, and 7h exhibited pronounced stronger activity than that of the positive control etoposide (VP-16). 4 beta-N-Substituted derivatives of 4'-O-demethylpodophyllotoxin were worthy of further study with potential antitumor activity.
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收藏
页码：628 / 633
页数：6
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