Stm1 modulates translation after 80S formation in Saccharomyces cerevisiae

被引：54

作者：

Balagopal, Vidya

Parker, Roy ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA

[2] Univ Arizona, Howard Hughes Med Inst, Tucson, AZ 85721 USA

来源：

RNA | 2011年 / 17卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Stm1; ribosomes; translation elongation; Dhh1; Pat1; ELONGATION-FACTOR; 3; NO-GO DECAY; MESSENGER-RNAS; BINDING PROTEIN; INITIATION; RIBOSOME; DISSOCIATION; DROSOPHILA; MECHANISM; DELETION;

D O I：

10.1261/rna.2677311

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The control of translation is a critical aspect of gene regulation. It is often inversely related to mRNA degradation and is typically controlled during initiation. The Stm1 protein in Saccharomyces cerevisiae has been shown to interact with ribosomes, affect the interaction of eEF3 with ribosomes, and promote the decapping of a subclass of mRNAs. We demonstrate that in vitro Stm1 inhibits translation after formation of an 80S complex. This suggests that Stm1 modulates translation and mRNA decapping by controlling translation elongation.

引用

页码：835 / 842

页数：8

共 31 条

[1] Mechanism of ribosomal subunit joining during eukaryotic translation initiation [J].