Enantioselective total synthesis of a novel polyketide natural product (+)-integrasone, an HIV-1 integrase inhibitor

被引：19

作者：

Mehta, G ^{[1
]}

Roy, S ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 25期

关键词：

D O I：

10.1039/b502024g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio-, chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.

引用

页码：3210 / 3212

页数：3

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