COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries

被引：28

作者：

Tan, Eng Hooi ^{[1
]}

Sena, Anthony G. ^{[2
,3
]}

Prats-Uribe, Albert ^{[1
]}

You, Seng Chan ^{[4
]}

Ahmed, Waheed-Ul-Rahman ^{[5
,6
]}

Kostka, Kristin ^{[7
]}

Reich, Christian ^{[7
]}

Duvall, Scott L. ^{[8
,9
]}

Lynch, Kristine E. ^{[8
,9
]}

Matheny, Michael E. ^{[10
,11
]}

Duarte-Salles, Talita ^{[12
]}

Bertolin, Sergio Fernandez ^{[12
]}

Hripcsak, George ^{[13
,14
]}

Natarajan, Karthik ^{[13
,14
]}

Falconer, Thomas ^{[13
]}

Spotnitz, Matthew ^{[13
]}

Ostropolets, Anna ^{[13
]}

Blacketer, Clair ^{[2
,3
]}

Alshammari, Thamir M. ^{[15
]}

Alghoul, Heba ^{[16
]}

Alser, Osaid ^{[17
]}

Lane, Jennifer C. E. ^{[1
]}

Dawoud, Dalia M. ^{[18
]}

Shah, Karishma ^{[5
]}

Yang, Yue ^{[19
]}

Zhang, Lin ^{[20
,21
]}

Areia, Carlos ^{[22
]}

Golozar, Asieh ^{[23
,24
]}

Recalde, Martina ^{[12
,25
]}

Casajust, Paula ^{[26
]}

Jonnagaddala, Jitendra ^{[27
]}

Subbian, Vignesh ^{[28
]}

Vizcaya, David ^{[29
]}

Lai, Lana Y. H. ^{[30
]}

Nyberg, Fredrik ^{[31
]}

Morales, Daniel R. ^{[32
]}

Posada, Jose D. ^{[33
]}

Shah, Nigam H. ^{[33
]}

Gong, Mengchun ^{[34
]}

Vivekanantham, Arani ^{[5
]}

Abend, Aaron ^{[35
]}

Minty, Evan P. ^{[36
]}

Suchard, Marc ^{[37
]}

Rijnbeek, Peter ^{[3
]}

Ryan, Patrick B. ^{[2
,13
]}

Prieto-Alhambra, Daniel ^{[1
]}

机构：

[1] Univ Oxford, Ctr Stat Med, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 7LD, England

[2] Janssen Res & Dev, Titusville, NJ USA

[3] Erasmus MC, Dept Med Informat, Rotterdam, Netherlands

[4] Ajou Univ, Dept Biomed Informat, Sch Med, Suwon, South Korea

[5] Univ Oxford, Botnar Res Ctr, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England

[6] Univ Exeter, Coll Med & Hlth, Exeter 2LU, Devon, England

[7] IQVIA, Real World Solut, Cambridge, MA USA

[8] VA Salt Lake City Hlth Care Syst, VA Informat & Comp Infrastruct, Salt Lake City, UT USA

[9] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT USA

[10] Tennessee Valley Healthcare Syst, Vet Affairs Med Ctr, Nashville, TN USA

[11] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA

[12] Fundacio Inst Univ Recerca Atencio Primaria Salut, Barcelona, Spain

[13] Columbia Univ, Dept Biomed Informat, New York, NY USA

[14] New York Presbyterian Hosp, New York, NY USA

[15] King Saud Univ, Medicat Safety Res Chair, Riyadh, Saudi Arabia

[16] Islamic Univ Gaza, Fac Med, Gaza, Palestine

[17] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02114 USA

[18] Cairo Univ, Fac Pharm, Cairo, Egypt

[19] Digital China Hlth Technol Co LTD, Beijing 100085, Peoples R China

[20] Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Beijing 100730, Peoples R China

[21] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3015, Australia

[22] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England

[23] Regeneron Pharmaceut, Tarrytown, NY USA

[24] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[25] Univ Autonoma Barcelona, Bellaterra, Spain

[26] Real World Evidence, Trial Form Support, Barcelona, Spain

[27] UNSW Sydney, Sch Publ Hlth & Community Med, Sydney, NSW, Australia

[28] Univ Arizona, Coll Engn, Tucson, AZ 85721 USA

[29] Bayer Pharmaceut, Barcelona, Spain

[30] Univ Manchester, Sch Med Sci, Manchester, Lancs, England

[31] Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Inst Med, Gothenburg, Sweden

[32] Univ Dundee, Div Populat Hlth Sci, Dundee, Scotland

[33] Stanford Univ, Dept Med, Stanford Ctr Biomed Informat Res, Sch Med, Stanford, CA 94305 USA

[34] Southern Med Univ, Hlth Management Inst, Guangzhou, Peoples R China

[35] Autoimmune Registry Inc, Guilford, CT 06437 USA

[36] Univ Calgary, Fac Med, OBrien Sch Publ Hlth, Calgary, AB T2N 1N4, Canada

[37] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA USA

来源：

RHEUMATOLOGY | 2021年 / 60卷

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

COVID-19; autoimmune condition; mortality; hospitalization; open science; Observational Health Data Sciences and Informatics (OHDSI); Observational Medical Outcomes Partnership (OMOP); VENOUS THROMBOEMBOLISM; CLINICAL-COURSE; SERIES;

D O I：

10.1093/rheumatology/keab250

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza. Methods. A multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum (USA), Department of Veterans Affairs (USA), Information System for Research in Primary Care-Hospitalization Linked Data (Spain) and claims data from IQVIA Open Claims (USA) and Health Insurance and Review Assessment (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalized between January and June 2020 with COVID-19, and similar patients hospitalized with influenza in 2017-18 were included. Outcomes were death and complications within 30days of hospitalization. Results. We studied 133589 patients diagnosed and 48418 hospitalized with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged >= 50years with previous comorbidities. The prevalence of hypertension (45.5-93.2%), chronic kidney disease (14.0-52.7%) and heart disease (29.0-83.8%) was higher in hospitalized vs diagnosed patients with COVID-19. Compared with 70660 hospitalized with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2.2-4.3% vs 6.32-24.6%). Conclusion. Compared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.

引用

页码：SI37 / SI50

页数：14

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