Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma

被引：39
|
作者：
Ma, Chao [1 ]
Peng, Chunyan [1 ]
Lu, Xuejia [1 ]
Ding, Xiwei [1 ]
Zhang, Shu [1 ]
Zou, Xiaoping [1 ]
Zhang, Xiaoqi [1 ]
机构：
[1] Nanjing Univ, Sch Med, Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 458卷 / 02期
基金：
美国国家科学基金会;
关键词：
FOXP3; Cholangiocarcinoma; Invasion; Immune escape; GASTRIC-CANCER; TUMOR-CELLS; T-CELLS; EXPRESSION; STAT3; SORAFENIB; MECHANISM; REPRESSOR;
D O I：
10.1016/j.bbrc.2015.01.067
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing the quantity of MMP-9 and MMP-2. With FOXP3 knocking down, IL-10 and TGF-beta 1 secreted by cancer cells diminishes and the cell survival of T cells is significant up-regulation. These results suggest that FOXP3 plays an important role in tumor malignant phenotype, especially the invasion and immune escape. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：234 / 239
页数：6
相关论文
共 50 条
  • [41] Rescue of Foxp3 deficiency by inducible activation of a bicistronic Foxp3/EGFP allele
    Lin, W
    Truong, N
    Haribhai, D
    Williams, CB
    Chatila, TA
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) : S83 - S83
  • [42] From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
    Bacchetta, Rosa
    Barzaghi, Federica
    Roncarolo, Maria-Grazia
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2018, 1417 (01) : 5 - 22
  • [43] FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity
    Zhaocai Zhou
    Xiaomin Song
    Bin Li
    Mark I. Greene
    Immunologic Research, 2008, 42 : 19 - 28
  • [44] FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity
    Zhou, Zhaocai
    Song, Xiaomin
    Li, Bin
    Greene, Mark I.
    IMMUNOLOGIC RESEARCH, 2008, 42 (1-3) : 19 - 28
  • [45] FOXP3 inhibits inducible NFAT2 gene expression.
    Torgerson, Troy
    Genin, Anna
    Anover, Stephanie
    Ocheltree, Elizabeth
    Frank, Bart
    Dozmorov, Igor
    Centola, Michael
    Ochs, Hans
    Cron, Randy
    CLINICAL IMMUNOLOGY, 2006, 119 : S7 - S8
  • [46] Functional Analysis of FOXP3
    Buckner, Jane H.
    Ziegler, Steven F.
    YEAR IN IMMUNOLOGY 2008, 2008, 1143 : 151 - 169
  • [47] Foxp3 and dominant tolerance
    Rudensky, A
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1461) : 1645 - 1646
  • [48] Human FOXP3 and cancer
    Martin, F.
    Ladoire, S.
    Mignot, G.
    Apetoh, L.
    Ghiringhelli, F.
    ONCOGENE, 2010, 29 (29) : 4121 - 4129
  • [49] What turns on Foxp3?
    Harald von Boehmer
    Jens Nolting
    Nature Immunology, 2008, 9 : 121 - 122
  • [50] FoxP3 partners up
    David Bending
    Masahiro Ono
    Nature Immunology, 2017, 18 : 1181 - 1183
12345