Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma

被引：39
|
作者：
Ma, Chao [1 ]
Peng, Chunyan [1 ]
Lu, Xuejia [1 ]
Ding, Xiwei [1 ]
Zhang, Shu [1 ]
Zou, Xiaoping [1 ]
Zhang, Xiaoqi [1 ]
机构：
[1] Nanjing Univ, Sch Med, Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 458卷 / 02期
基金：
美国国家科学基金会;
关键词：
FOXP3; Cholangiocarcinoma; Invasion; Immune escape; GASTRIC-CANCER; TUMOR-CELLS; T-CELLS; EXPRESSION; STAT3; SORAFENIB; MECHANISM; REPRESSOR;
D O I：
10.1016/j.bbrc.2015.01.067
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing the quantity of MMP-9 and MMP-2. With FOXP3 knocking down, IL-10 and TGF-beta 1 secreted by cancer cells diminishes and the cell survival of T cells is significant up-regulation. These results suggest that FOXP3 plays an important role in tumor malignant phenotype, especially the invasion and immune escape. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：234 / 239
页数：6
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