No impact of passive smoke on the somatic profile of lung cancers in never-smokers

被引：19

作者：

Couraud, Sebastien ^{[1
,2
]}

Debieuvre, Didier ^{[3
]}

Moreau, Lionel ^{[4
]}

Dumont, Patrick ^{[5
]}

Margery, Jacques ^{[6
]}

Quoix, Elisabeth ^{[7
]}

Duvert, Bernard ^{[8
]}

Cellerin, Laurent ^{[9
]}

Baize, Nathalie ^{[10
]}

Taviot, Bruno ^{[11
]}

Coudurier, Marie ^{[12
,13
]}

Cadranel, Jacques ^{[14
,15
]}

Missy, Pascale ^{[16
]}

Morin, Franck ^{[16
]}

Mornex, Jean-Francois ^{[17
]}

Zalcman, Gerard ^{[18
]}

Souquet, Pierre-Jean ^{[1
,2
]}

机构：

[1] Hosp Civils Lyon, Lyon Sud Hosp, Acute Resp & Thorac Oncol Unit, Pierre Benite, France

[2] Univ Lyon 1, Fac Med Lyon Sud Charles Merieux, Oullins, France

[3] Emile Muller Hosp, Ctr Hosp Mulhouse, Pulmonol & Thorac Oncol Unit, Mulhouse, France

[4] Hop Civils, Resp Med, Colmar, France

[5] Chauny Hosp, Resp Med & Thorac Oncol Unit, Chauny, France

[6] Hop Instruct Armees Percy, Serv Malad Resp, Clamart, France

[7] Univ Strasbourg, NHC, Dept Pneumol, Strasbourg, France

[8] Montelimar Hosp, Resp Med, Montelimar, France

[9] CHU Nantes, Inst Thorax, Serv Pneumol, F-44035 Nantes 01, France

[10] CHU Angers, Pole Specialites Med & Chirurg Integrees, Angers, France

[11] Ctr Med Nicolas de Pontoux, Chalon Sur Saone, France

[12] Chambery Hosp, Pulmonol Unit, Chambery, France

[13] Chambery Hosp, Thorac Oncol Unit, Chambery, France

[14] Hop Tenon, AP HP, Serv Pneumol, F-75970 Paris, France

[15] Univ Paris 06, Sorbonne Univ, GRC Theranoscan 04, Paris, France

[16] Intergrp Francophone Cancerol Thorac, Paris, France

[17] Univ Lyon 1, INRA, UMR754, Hosp Civils Lyon, F-69365 Lyon, France

[18] Caen Basse Normandie Univ, INSERM, UMR 1086, Pulmonol & Thorac Oncol Dept,Caen Univ Hosp, Caen, France

来源：

EUROPEAN RESPIRATORY JOURNAL | 2015年 / 45卷 / 05期

关键词：

ENVIRONMENTAL TOBACCO-SMOKE; GROWTH-FACTOR RECEPTOR; 2ND-HAND SMOKE; EXPOSURE; MUTATIONS; SECONDHAND; RISK; EGFR; PATTERNS; EML4-ALK;

D O I：

10.1183/09031936.00097314

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

EGFR and HER2 mutations and ALK rearrangement are known to be related to lung cancer in never-smokers, while KRAS, BRAF and PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a "smoker-like" somatic profile compared with unexposed never-smokers. Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled. Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFR mutation: 46% in never exposed versus 41% in ever exposed; KRAS: 7% versus 7%; ALK: 13% versus 11%; HER2: 4% versus 5%; BRAF: 6% versus 5%; PIK3CA: 4% versus 2%). We observed a nonsignificant trend for a negative association between EGFR mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers. There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer.

引用

页码：1415 / 1425

页数：11

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