Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy

被引：79

作者：

Schmitt, Nicole C. ^{[1
,2
]}

Kang, Hyunseok ^{[3
]}

Sharma, Arun ^{[4
]}

机构：

[1] Natl Inst Deafness & Other Commun Disorders, Integrat Therapeut Program, NIH, Bethesda, MD USA

[2] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA

[3] Johns Hopkins Med Inst, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA

[4] Southern Illinois Univ, Div Otolaryngol Head & Neck Surg, Springfield, IL USA

来源：

ORAL ONCOLOGY | 2017年 / 74卷

关键词：

Salivary duct carcinoma; Salivary malignancy; ErbB2; GROWTH-FACTOR RECEPTOR; METASTATIC BREAST-CANCER; ANDROGEN-RECEPTOR; PAROTID-GLAND; PROGNOSTIC-FACTORS; HER2; EXPRESSION; CLINICOPATHOLOGICAL FEATURES; IMMUNOHISTOCHEMICAL ANALYSIS; POSTOPERATIVE RADIOTHERAPY; MOLECULAR CHARACTERIZATION;

D O I：

10.1016/j.oraloncology.2017.09.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several large single-institution series and national database searches. Recent studies of genomic alterations have helped elucidate the biology and pathogenesis of this aggressive disease. Here we review outcomes of the disease, effects of treatment, prognostic factors, and genomic alterations in SDC. Studies of targeted therapy and promising future directions are also discussed.

引用

页码：40 / 48

页数：9

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