MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

被引：118

作者：

Vargova, Karin ^{[1
,2
]}

Curik, Nikola ^{[1
,2
]}

Burda, Pavel ^{[1
,2
]}

Basova, Petra ^{[1
,2
]}

Kulvait, Vojtech ^{[1
,2
]}

Pospisil, Vit ^{[1
,2
]}

Savvulidi, Filipp ^{[1
,2
]}

Kokavec, Juraj ^{[1
,2
]}

Necas, Emanuel ^{[1
,2
]}

Berkova, Adela ^{[3
]}

Obrtlikova, Petra ^{[1
,2
,3
]}

Karban, Josef ^{[1
,2
,3
]}

Mraz, Marek ^{[4
,5
]}

Pospisilova, Sarka ^{[4
,5
]}

Mayer, Jiri ^{[4
,5
]}

Trneny, Marek ^{[1
,2
,3
]}

Zavadil, Jiri ^{[1
,2
,6
,7
]}

Stopka, Tomas ^{[1
,2
,3
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Prague 12853 2, Czech Republic

[2] Charles Univ Prague, Ctr Expt Hematol, Prague 12853 2, Czech Republic

[3] Gen Fac Hosp, Med Dept Hematol 1, Prague, Czech Republic

[4] Masaryk Univ, Fac Med, Brno, Czech Republic

[5] Masaryk Univ, Univ Hosp Brno, Dept Internal Med Hematooncol, Brno, Czech Republic

[6] NYU, Inst Canc, Langone Med Ctr, New York, NY USA

[7] NYU, Langone Med Ctr, Ctr Hlth Informat & Bioinformat, New York, NY USA

来源：

BLOOD | 2011年 / 117卷 / 14期

关键词：

B-CELL-DIFFERENTIATION; C-MYB; HIGH EXPRESSION; PU.1; MICRORNA-155; TRANSFORMATION; LYMPHOMA; GROWTH; ROLES; RNA;

D O I：

10.1182/blood-2010-05-285064

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription. (Blood. 2011; 117(14):3816-3825)

引用

页码：3816 / 3825

页数：10

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