Synthesis of a Combinatorial Library of Amides and Its Evaluation against the Fall Armyworm, Spodoptera frugiperda

被引：21

作者：

Castral, Thais C. ^{[1
]}

Matos, Andreia P. ^{[1
]}

Monteiro, Julia L. ^{[1
]}

Araujo, Fernanda M. ^{[1
]}

Bondancia, Tatiani M. ^{[1
]}

Batista-Pereira, Luciane G. ^{[1
]}

Fernandes, Joao B. ^{[1
]}

Vieira, Paulo C. ^{[1
]}

da Silva, M. Fatima G. F. ^{[1
]}

Correa, Arlene G. ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

Spodoptera frugiperda; Lepidoptera; insecticidal activity; combinatorial library; piperamides; LEPIDOPTERA-NOCTUIDAE; SPECIALIST HERBIVORES; NATURAL-PRODUCTS; GENERALIST; PIPERACEAE; PYRALIDAE; EXTRACTS; SMITH;

D O I：

10.1021/jf104903t

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The fall armyworm Spodoptera frugiperda is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work we describe the preparation of an indexed combinatorial library of amides and its toxic effect by contact against S. frugiperda . (E)-1-(1-Piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one was the most active compound with an LD(50) = 0.793 mu g mg(-1) of larva. This amide was also evaluated by ingestion and at the lowest concentration (1 mg kg(-1)) achieved 83.3% mortality.

引用

页码：4822 / 4827

页数：6

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