Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

被引：49
作者：
Crispino, Marianna [1 ]
Volpicelli, Floriana [2 ]
Perrone-Capano, Carla [2 ,3 ]
机构：
[1] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy
[2] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy
[3] CNR, Natl Res Council, Inst Genet & Biophys Adriano Buzzati Traverso, I-80131 Naples, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 02期
关键词：
brain connectivity; brain development; gut-brain axis; neurodevelopmental diseases; neuronal cytoarchitecture; neuroplasticity; regulatory T cells; serotonin (5-HT); AUTISM SPECTRUM DISORDER; 5-HT7; RECEPTOR; MITOCHONDRIAL DYSFUNCTION; STRUCTURAL PLASTICITY; SYNAPTIC PLASTICITY; NEURITE OUTGROWTH; DENDRITIC SPINES; DEFICIENT MICE; FEMALE MICE; IN-VITRO;
D O I：
10.3390/ijms21020505
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology have advanced considerably in recent years. A wealth of data show that 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows the rescue of long-term potentiation (LTP) and long-term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, modulates the function of immune cells, and is likely to play a role in the gut-brain axis. In this review, we will mainly focus on recent findings on this receptor's role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gastrointestinal (GI) tract and immune system.
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页数：18
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