Peripapillary and Macular Choroidal Vascularity Index in Eyes with Fuchs' Uveitis

Background: To investigate the choroidal vascularity alterations of macula and peripapillary area in eyes with unilateral Fuchs uveitis (FU). Methods: This study included 18 eyes with unilateral FU and 18 healthy fellow eyes. The choroidal vascularity index (CVI) was analyzed, and the results were compared between eyes with FU and healthy fellow eyes (control group). Results: The mean subfoveal (s)CVI (%) value was significantly lower in the FU group as compared with the control group: 60.92 +/- 2.63 vs. 64.01 +/- 2.54, respectively (p = .001). The mean pCVI (%) values of superior and inferior quadrant were significantly lower in the Fuchs group as compared with the control group:58.87 +/- 4.48 vs. 61.98 +/- 3.32, respectively, in superior quadrant (p = .035); and 57.29 +/- 6.65 vs. 61.44 +/- 4.76, respectively, in inferior quadrant (p = .014). Conclusion: The chronic continuous inflammation in FU causes inflammation-mediated thinning in the vascular area of the subfoveal and peripapillary choroid. The changes in the peripapillary region are remarkable in terms of the further glaucoma risk of these eyes.