Nonhuman Primate Models of Human Immunology

被引：113

作者：

Messaoudi, Ilhem ^{[1
,2
,3
]}

Estep, Ryan

Robinson, Bridget

Wong, Scott W. ^{[2
,3
]}

机构：

[1] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Vaccine & Gene Therapy Inst, Beaverton, OR 97006 USA

[2] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Beaverton, OR 97006 USA

[3] Oregon Natl Primate Res Ctr, Div Pathobiol & Immunol, Beaverton, OR USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 14卷 / 02期

关键词：

KERATINOCYTE GROWTH-FACTOR; T-CELL SENESCENCE; MEMORY B-CELLS; DIETARY RESTRICTION; CALORIC RESTRICTION; RHESUS-MONKEYS; DENDRITIC CELLS; PERIPHERAL-BLOOD; CLONAL EXPANSIONS; TCR REPERTOIRE;

D O I：

10.1089/ars.2010.3241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system. Antioxid. Redox Signal. 14, 261-273.

引用

页码：261 / 273

页数：13

共 109 条

[11] IGHV1, IGHV5 and IGHV7 subgroup genes in the Rhesus macaque [J].