Does Human Alpha-Synuclein Behave Like Prions?

被引：1

作者：

Siddique, Yasir Hasan ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Sect Genet,Drosophila Transgen Lab, Aligarh 202002, Uttar Pradesh, India

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2021年 / 20卷 / 06期

关键词：

alpha-synuclein; Parkinson's Disease; prions; human; Lewy bodies; synaptic vesicles; QUAKING-INDUCED CONVERSION; PARKINSONS-DISEASE; AGGREGATION; MODEL; NEURODEGENERATION; PATHOLOGY; FEATURES;

D O I：

10.2174/1871527320666210420140123

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alpha-synuclein (alpha-synuclein) is a protein that is abundantly found in the brain and in a lesser amount in the heart and muscles. The exact role of alpha-synucleinis is not known, but it is considered to control the movement of synaptic vesicles. Its overexpression in the neurons leads to the formation of Lewy bodies that damage the dopaminergic neurons in the subtantianigra of the midbrain and leads to the progression of Parkinson's Disease (PD). There are evidences showing that aggregates of alpha-synuclein behave like prions. The present review is an attempt to put forth the nature of alpha-synuclein as prions.

引用

页码：480 / 486

页数：7

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