New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron

被引：18
作者：
Adrian, PV
du Plessis, M
Klugman, KP
Amyes, SGB
机构：
[1] S African Inst Med Res, Dept Med Microbiol, ZA-2000 Johannesburg, South Africa
[2] Univ Witwatersrand, Dept Med Microbiol, Johannesburg, South Africa
[3] Univ Edinburgh, Dept Med Microbiol, Edinburgh, Midlothian, Scotland
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 09期
关键词：
D O I：
10.1128/AAC.42.9.2221
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respectively. Genes for spectinomycin resistance, aadA1 [ant (3 ")-Ia], and sulfonamide resistance, sul1, were located downstream of dfrXV in a manner identical to that in pLMO229.
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页码：2221 / 2224
页数：4
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