Prognostic value of neutrophil-to-lymphocyte ratio and other inflammatory markers in patients with high-risk soft tissue sarcomas

被引：22

作者：

Vinal, D. ^{[1
]}

Martinez, D. ^{[1
]}

Garcia-Cuesta, J. A. ^{[1
]}

Gutierrez-Sainz, L. ^{[1
]}

Martinez-Recio, S. ^{[1
]}

Villamayor, J. ^{[1
]}

Martinez-Marin, V. ^{[1
,8
]}

Gallego, A. ^{[1
]}

Ortiz-Cruz, E. ^{[2
]}

Mendiola, M. ^{[3
,9
]}

Pozo-Kreilinger, J. J. ^{[3
,4
,7
]}

Berjon, A. ^{[4
]}

Belinchon, B. ^{[5
]}

Bernabeu, D. ^{[6
]}

Espinosa, E. ^{[1
,7
,8
,9
,10
]}

Feliu, J. ^{[1
,7
,8
,9
,10
]}

Redondo, A. ^{[1
,7
,8
,10
]}

机构：

[1] Hosp Univ La Paz, IdiPAZ, Dept Med Oncol, Madrid, Spain

[2] Hosp Univ La Paz, Dept Orthopaed Surg, Paseo Castellana 261, Madrid 28046, Spain

[3] IdiPAZ, Mol Pathol & Therapeut Targets Grp, Madrid, Spain

[4] Hosp Univ La Paz, Dept Pathol, Madrid, Spain

[5] Hosp Univ La Paz, Dept Radiat Oncol, Madrid, Spain

[6] Hosp Univ La Paz, Dept Radiol, Madrid, Spain

[7] Univ Autonoma Madrid, Fac Med, Madrid, Spain

[8] IdiPAZ, Translat Oncol Grp, Madrid, Spain

[9] CIBERONC, Madrid, Spain

[10] Catedra UAM AMGEN, Madrid, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2020年 / 22卷 / 10期

关键词：

Soft tissue sarcomas; Neutrophil-to-lymphocyte ratio; Chemotherapy; C-REACTIVE PROTEIN; NEUTROPHIL/LYMPHOCYTE RATIO; ADULT PATIENTS; CHEMOTHERAPY; EXTREMITY; NOMOGRAMS; SURVIVAL; PREDICT; TRUNK;

D O I：

10.1007/s12094-020-02324-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Soft tissue sarcomas (STS) have a high risk of relapse in spite of the use of (neo)adjuvant chemotherapy. In this context, looking for new prognostic biomarkers is an interesting field of research. Our aim is to analyze the prognostic impact of neutrophil-to-lymphocyte ratio (NLR) and other serum markers in patients with STS who received chemotherapy with curative intent. Materials and methods This is a retrospective observational study. We included all patients with STS (primary tumor, local recurrence or resected metastatic disease) treated with high-dose ifosfamide and epirubicin with curative intent from January 2007 to December 2018. The pretreatment NLR and other serum markers were calculated, selecting the median as the cut-off value for the survival and multivariate analysis. Results Seventy-nine patients were included. Median NLR, platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) were 2.83, 174.05 and 3.25, respectively. Median progression-free survival (PFS) was significantly longer in patients with low NLR [not reached (NR) vs 21, 92 months, P < 0.01]. No significant differences were found for PFS regarding PLR or LMR. For overall survival (OS), a significant survival advantage was also found for patients with low NLR (NR vs 65.45 months, P = 0.01), without differences for PLR or LMR. In multivariate analysis, NLR remains an independent prognostic factor for PFS. Conclusion In our cohort, low NLR was significantly associated with a longer PFS and OS, and is consolidated as an independent prognostic factor.

引用

页码：1849 / 1856

页数：8

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