Efficacy and effects of transdermal hormone therapy in postmenopausal women

被引：0
作者：
Prado Correia, L. E. [1 ]
de Almeida, B. C. [2 ]
Chada Baracat, E. [2 ]
Silva, I [1 ]
Soares Junior, J. M. [2 ]
Bonduki, C. E. [1 ]
Abi Haidar, M. [1 ]
机构：
[1] Fed Univ Sao Paulo UNIFESP, EPM, Climacter Sect, Dept Obstet & Gynecol, Vila Clementino, Sao Paulo, Brazil
[2] Univ Sao Paulo, Lab Mol & Struct Gynecol, Hosp Clin, Fac Med FMUSP, Sao Paulo, Brazil
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2018年 / 45卷 / 05期
关键词：
Transdermal hormone therapy; Postmenopausal women; 17-beta-estradiol; Oral micronized progesterone; Medroxyprogesterone acetate; ESTROGEN-REPLACEMENT THERAPY; VENOUS THROMBOEMBOLISM RISK; ESTROGEN/PROGESTERONE REGIMENS; CONJUGATED ESTROGENS; HEMOSTASIS VARIABLES; BLOOD-COAGULATION; CONTROLLED-TRIAL; FIBRINOLYSIS; ESTRADIOL; METAANALYSIS;
D O I：
10.12891/ceog4328.2018
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The authors aimed to evaluate the influence of transdermal hormone therapy (I IT) in the blood coagulation parameters. Fifty-eight postmenopausal women received: G1-transdermal estradiol (E2) (50 mg), G2-E2+oral micronized progesterone (100 mg/day), and G3-F2+ +oral medroxyprogesterone acetate (2.5 mg/day) for six months. Statistical relevance was seen mainly in G1 and G2. G1 showed a decrease in prothrombin time (PT), fibrinogen (FG), and thrombin time (TT) at six months (p < 0.05) compared to baseline values. G2 showed an increase of PT (p < 0.05) and a reduction of activated partial thromboplastin time (aPTT). AT III at three months (p < 0.01). AT RI showed an increase after six months (p < 0.05), as well as F1 + 2 (p < 0.05). G3 exhibited a decrease of PT after three and six months of transdermal LIT. Data suggests that E2 alone or E2 + OMP are correlated with some variations of anticoagulant and procoagulant factors. E2 I MPA avoids any major activation of blood coagulation in patients who receive transdermal FIT.
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页码：735 / 740
页数：6
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