The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

被引：100
作者：
Punt, Simone [1 ]
Langenhoff, Jessica M. [2 ]
Putter, H. [3 ]
Fleuren, Gert Jan [1 ]
Gorter, Arko [1 ]
Jordanova, Ekaterina S.
机构：
[1] Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Walaeus Lib, Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Leiden, Netherlands
来源：
ONCOIMMUNOLOGY | 2015年 / 4卷 / 02期
关键词：
cancer; IL-17; survival; tumor microenvironment; Th17; CD4(+) T-CELLS; MESSENGER-RNA; TUMOR MICROENVIRONMENT; IL-17-PRODUCING CELLS; PROMOTES ANGIOGENESIS; CLINICAL-RELEVANCE; POOR-PROGNOSIS; BONE-MARROW; EXPRESSION; INTERLEUKIN-17;
D O I：
10.4161/2162402X.2014.984547
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17(+) cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17(+) cells.
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页码：1 / 10
页数：10
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