Catalytic enantioselective allylation at the activated benzylic position of prochiral aryl cyano esters: access to quaternary stereogenic centers

被引：11
|
作者：
Nowicki, A [1 ]
Mortreux, A [1 ]
Agbossou-Niedercorn, F [1 ]
机构：
[1] ENSCL, CNRS, UMR 8010, Lab Catalyse Lille, F-59652 Villeneuve Dascq, France
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 10期
关键词：
asymmetric allylation; palladium; quaternary centers; asymmetric catalysis;
D O I：
10.1016/j.tetlet.2005.01.082
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium catalyzed asymmetric allylic alkylation of prochiral aryl cyano esters has been carried out in the presence of various chiral ligands. The base and additives have been varied and allowed to produce the allyl derivative presenting a highly functionalized quaternary stereogenic center. The chiral pocket ligands of Trost appears the most appropriate to produce the desired chiral derivative. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1617 / 1621
页数：5
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