2-Acetylthienopyridine Synthesis via Thiolation and Copper Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate

被引：24

作者：

Li, Yibiao ^{[1
]}

Luo, Xianglin ^{[1
]}

Shao, Yan ^{[1
]}

Chen, Lu ^{[1
]}

机构：

[1] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529090, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 15期

基金：

中国国家自然科学基金;

关键词：

2-FLUOROPHENYLACETYLENE DERIVATIVES; CASCADE SEQUENCE; THIENOPYRIDINE; INHIBITORS; ANNULATION; DISCOVERY; SULFUR; IDENTIFICATION; EXPRESSION; PRASUGREL;

D O I：

10.1021/acs.joc.8b01037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source. Moreover, excellent chemoselectivity, broad substrate scope, and good functional group tolerance are prominent features of this transformation.

引用

页码：8768 / 8774

页数：7

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