EFFECTS IN SHORT-TERM OF ALLOXAN APPLICATION TO DIABETES INDUCTION IN WISTAR RATS

被引：0

作者：

Curiacos de Almeida Leme, Jose Alexandre ^{[1
]}

Castellar, Alexandre ^{[2
]}

Remedio, Rafael Neodini ^{[2
]}

Barbosa, Rodrigo Avelaira ^{[2
]}

de Moura, Leandro Pereira ^{[1
]}

Dalia, Rodrigo Augusto ^{[1
]}

Gomes, Ricardo Jose ^{[3
]}

Caetano, Flavio Henrique ^{[4
]}

Rostom de Mello, Maria Alice ^{[1
]}

Luciano, Eliete ^{[1
]}

机构：

[1] Univ Estadual Paulista, Dept Educ Fis, Sao Paulo, Brazil

[2] Univ Estadual Paulista, Dept Biol, Sao Paulo, Brazil

[3] Univ Fed Sao Paulo Baixada Santista, Sao Paulo, Brazil

[4] Univ Estadual Paulista, Dept Ciencias Biol, Sao Paulo, Brazil

来源：

BIOSCIENCE JOURNAL | 2010年 / 26卷 / 03期

关键词：

Alloxan; Diabetes; Metabolism; Immune System; INSULIN; CELL;

D O I：

暂无

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.

引用

页码：442 / 447

页数：6

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