EFFECTS IN SHORT-TERM OF ALLOXAN APPLICATION TO DIABETES INDUCTION IN WISTAR RATS

被引：0

作者：

Curiacos de Almeida Leme, Jose Alexandre ^{[1
]}

Castellar, Alexandre ^{[2
]}

Remedio, Rafael Neodini ^{[2
]}

Barbosa, Rodrigo Avelaira ^{[2
]}

de Moura, Leandro Pereira ^{[1
]}

Dalia, Rodrigo Augusto ^{[1
]}

Gomes, Ricardo Jose ^{[3
]}

Caetano, Flavio Henrique ^{[4
]}

Rostom de Mello, Maria Alice ^{[1
]}

Luciano, Eliete ^{[1
]}

机构：

[1] Univ Estadual Paulista, Dept Educ Fis, Sao Paulo, Brazil

[2] Univ Estadual Paulista, Dept Biol, Sao Paulo, Brazil

[3] Univ Fed Sao Paulo Baixada Santista, Sao Paulo, Brazil

[4] Univ Estadual Paulista, Dept Ciencias Biol, Sao Paulo, Brazil

来源：

BIOSCIENCE JOURNAL | 2010年 / 26卷 / 03期

关键词：

Alloxan; Diabetes; Metabolism; Immune System; INSULIN; CELL;

D O I：

暂无

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.

引用

页码：442 / 447

页数：6

共 50 条

[31] Incretin secretion is not restored by short-term strict glycaemic control in Korean hyperglycaemic patients with type 2 diabetes
Lee, Seung-Hwan
Kim, Ji-Hyun
Shin, Jeong-Ah
Kim, Eun Sook
Cho, Jae-Hyoung
Ko, Seung-Hyun
Yoon, Kun-Ho
Ahn, Yu-Bae
DIABETES RESEARCH AND CLINICAL PRACTICE, 2011, 92 (01) : 74 - 81
[32] Experimental diabetes induced by streptozotocin in the desert gerbil, Gerbillus gerbillus, and the effects of short-term 20-hydroxyecdysone administration
Mallek, Aicha
Movassat, Jamileh
Ameddah, Souad
Liu, Junjun
Semiane, Nesrine
Khalkhal, Ali
Dahmani, Yasmina
BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 : 354 - 361
[33] Short-term Effects of Acute Kidney Injury
Singbartl, Kai
Joannidis, Michael
CRITICAL CARE CLINICS, 2015, 31 (04) : 751 - +
[34] Short-term effects of triiodothyronine on hypothyroid chickens
Rosebrough, R. W.
Russell, B. A.
Richards, M. P.
POULTRY SCIENCE, 2008, 87 : 88 - 88
[35] Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice
Brezar, Vedran
Culina, Slobodan
Gagnerault, Marie-Claude
Mallone, Roberto
EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (06) : 1553 - 1561
[36] Renal findings in patients with short-term type 2 diabetes
Keller, CK
Fliser, D
Ritz, E
Bergis, KH
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (12): : 2627 - 2635
[37] Hypothalamic insulin expression remains unaltered after short-term fasting in female rats
Dakic, Tamara B.
Markelic, Milica B.
Ruzicic, Aleksandra A.
Jevdjovic, Tanja, V
Lakic, Iva, V
Djordjevic, Jelena D.
Vujovic, Predrag Z.
ENDOCRINE, 2022, 78 (03) : 476 - 483
[38] α-Amylase and α-glucosidase inhibitor effects and pancreatic response to diabetes mellitus on Wistar rats of Ephedra alata areal part decoction with immunohistochemical analyses
Ben Lamine, Jihene
Boujbiha, Mouhamed Ali
Dahane, Sabra
Ben Cherifa, Amal
Khlifi, Aida
Chandoura, Hassiba
Yakoubi, Mouhamed Taher
Ferchichi, Salima
El Ayeb, Nacer
Achour, Lotfi
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2019, 26 (10) : 9739 - 9754
[39] The effects of empagliflozin on cardiometabolic risk factors in patients with type 2 diabetes: A short-term observational study
Chacko, Jithin
Dhandapani, Shankar
Jahagiridhar, Vidhya
Swaminathan, Krishnan
INDIAN JOURNAL OF PHARMACOLOGY, 2021, 53 (03) : 229 - 233
[40] EFFECTS OF GANGLIOSIDES ON THE METHIONINE UPTAKE IN CRUSHED SCIATIC-NERVES OF RATS WITH ALLOXAN DIABETES
BENECH, C
SOTELO, JR
MARTINEZ, R
CORREALUNA, R
NEUROSCIENCE LETTERS, 1990, 114 (02) : 220 - 224

← 1 2 3 4 5 →