Endemic Burkitt's lymphoma: a polymicrobial disease?

被引:121
作者
Rochford, R [1 ]
Cannon, MJ
Moormann, AM
机构
[1] SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA
[2] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
[3] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA
关键词
D O I
10.1038/nrmicro1089
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Endemic Burkitt's lymphoma is the most common childhood cancer in equatorial Africa. Two ubiquitous human pathogens are thought to be responsible for the aetiology of this disease: Epstein-Barr virus and Plasmodium falciparum malaria. New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis.
引用
收藏
页码:182 / 187
页数:6
相关论文
共 72 条
[1]   Expression of Epstein-Barr virus gene products in Burkitt's lymphoma in Northeast Brazil [J].
Araujo, I ;
Foss, HD ;
Bittencourt, A ;
Hummel, M ;
Demel, G ;
Mendonca, N ;
Herbst, H ;
Stein, H .
BLOOD, 1996, 87 (12) :5279-5286
[2]   The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell [J].
Babcock, GJ ;
Hochberg, D ;
Thorley-Lawson, DA .
IMMUNITY, 2000, 13 (04) :497-506
[3]  
Bacchi MM, 1996, MODERN PATHOL, V9, P63
[4]   Developing animal models for polymicrobial diseases [J].
Bakaletz, LO .
NATURE REVIEWS MICROBIOLOGY, 2004, 2 (07) :552-568
[5]   A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells [J].
Bernasconi, NL ;
Onai, N ;
Lanzavecchia, A .
BLOOD, 2003, 101 (11) :4500-4504
[6]   EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function [J].
Bickham, K ;
Münz, C ;
Tsang, ML ;
Larsson, M ;
Fonteneau, JF ;
Bhardwaj, N ;
Steinman, R .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (01) :121-130
[7]   PRIMARY EPSTEIN-BARR VIRUS-INFECTIONS IN AFRICAN INFANTS .2. CLINICAL AND SEROLOGICAL OBSERVATIONS DURING SEROCONVERSION [J].
BIGGAR, RJ ;
HENLE, G ;
BOCKER, J ;
LENNETTE, ET ;
FLEISHER, G ;
HENLE, W .
INTERNATIONAL JOURNAL OF CANCER, 1978, 22 (03) :244-250
[8]   PRIMARY EPSTEIN-BARR VIRUS-INFECTIONS IN AFRICAN INFANTS - DECLINE OF MATERNAL ANTIBODIES AND TIME OF INFECTION [J].
BIGGAR, RJ ;
HENLE, W ;
FLEISHER, G ;
BOCKER, J ;
LENNETTE, ET ;
HENLE, G .
INTERNATIONAL JOURNAL OF CANCER, 1978, 22 (03) :239-243
[9]   Human CD8+ T cell responses to EBV EBNA1:: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing [J].
Blake, N ;
Lee, S ;
Redchenko, I ;
Thomas, W ;
Steven, N ;
Leese, A ;
Steigerwald-Mullen, P ;
Kurilla, MG ;
Frappier, L ;
Rickinson, A .
IMMUNITY, 1997, 7 (06) :791-802
[10]   Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children [J].
Bloland, PB ;
Boriga, DA ;
Ruebush, TK ;
McCormick, JB ;
Roberts, JM ;
Oloo, AJ ;
Hawley, W ;
Lal, A ;
Nahlen, B ;
Campbell, CC .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 60 (04) :641-648