Risk of Retinal Artery Occlusion in Patients With End-Stage Renal Disease A Retrospective Large-Scale Cohort Study

被引：13

作者：

Chang, Yuh-Shin ^{[1
,5
]}

Weng, Shih-Feng ^{[2
,12
]}

Chang, Chun ^{[11
]}

Wang, Jhi-Joung ^{[2
,3
]}

Tseng, Sung-Huei ^{[1
,6
]}

Ko, Shun-Yao ^{[5
]}

Su, Shih-Bin ^{[4
,8
]}

Huang, Chien-Cheng ^{[4
,9
]}

Wang, Jiu-Yao ^{[7
]}

Jan, Ren-Long ^{[7
,10
]}

机构：

[1] Chang Jung Christian Univ, Coll Hlth Sci, Dept Ophthalmol, Tainan, Taiwan

[2] Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Res, Tainan, Taiwan

[3] Chang Jung Christian Univ, Coll Hlth Sci, Dept Anesthesiol, Tainan, Taiwan

[4] Chang Jung Christian Univ, Coll Hlth Sci, Chi Mei Med Ctr, Dept Occupat Med, Tainan, Taiwan

[5] Chang Jung Christian Univ, Coll Hlth Sci, Grad Inst Med Sci, Tainan, Taiwan

[6] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Ophthalmol, Tainan 701, Taiwan

[7] Natl Cheng Kung Univ, Grad Inst Clin Med, Tainan 701, Taiwan

[8] Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management, Tainan, Taiwan

[9] Southern Taiwan Univ Sci & Technol, Dept Child Care & Educ, Tainan, Taiwan

[10] Chi Mei Med Ctr, Dept Pediat, 201 Taikang, Tainan 73657, Taiwan

[11] Univ Taipei, Dept Educ, Taipei, Taiwan

[12] Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat, Kaohsiung, Taiwan

来源：

MEDICINE | 2016年 / 95卷 / 14期

关键词：

CHRONIC KIDNEY-DISEASE; ACUTE CORONARY SYNDROME; INTIMA-MEDIA THICKNESS; CAROTID ATHEROSCLEROSIS; MICROVASCULAR ABNORMALITIES; CALCIFICATION; HEMODIALYSIS; POPULATION; PREVALENCE; EYE;

D O I：

10.1097/MD.0000000000003281

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is globally increasing prevalence and incidence in end-stage renal disease (ESRD). These patients are frequently reported to have retinal abnormalities and both diseases share some systemic risk factors. Hence, it is clinically relevant to determine whether ESRD is a predictor of retinal artery occlusion (RAO). To investigate the risk of RAO in ESRD patients. A retrospective, nationwide, matched cohort study. The study included 93,766 ESRD patients recruited between 2000 and 2009 from the Taiwan National Health Insurance Research Database. The same number control group included age- and sex-matched patients without ESRD selected from the Taiwan Longitudinal Health Insurance Database, 2000. Data for each patient were collected from the index date until December 2011. The incidence and risk of RAO were compared between the 2 groups. The hazard ratio (HR) for RAO after adjustment for potential confounders was calculated using Cox proportional hazards regression. Kaplan-Meier analysis was used to calculate the cumulative RAO incidence rate. In total, 237 ESRD patients and 73 controls exhibited RAO during follow-up; thus, the RAO incidence rate in ESRD patients was 4.49 times (95% confidence interval (CI), 3.45-5.83) that in the control patients. After adjustment for potential confounders, including diabetes mellitus, hypertension, hyperlipidemia, congestive heart failure, and coronary artery disease, ESRD patients were 2.78 times (95% CI, 2.02-3.84) more likely to develop RAO in cohort for the total sample. Among patients with hypertension, the RAO incidence rate was significantly higher in the ESRD group, and hypertension significantly increased RAO risk even after adjustment for other confounders in the cohort. ESRD increases the risk of RAO, particularly in ESRD patients with hypertension. Therefore, clinicians should educate ESRD patients about RAO and ensure appropriate blood pressure control.

引用

页数：7

共 44 条

[41] The eye in hypertension [J].