Predictive value of combined detection of TSH, FT4 and gestational age and relevant factors for congenital hypothyroidism in newborns

Objective: This study aimed to study the predictive value of combined detection of TSH, FT4 and gestational age and analyze the relevant factors for congenital hypothyroidism (CH) in newborns. Methods: 46 neonates with hypothyroidism and 46 healthy neonates were randomly selected as the study group and control group, and serum TSH and FT4 were detected by electrochemical luminescence. The single and combined predictive value of serum TSH, FT4 and gestational age in neonates with hypothyroidism was analyzed, and the logistic regression analysis was used to analyze the influencing factors of neonatal hypothyroidism. Results: Serum TSH in study group was significantly higher than that in control group, serum FT4 and gestational age were significantly lower than those in the control group (P < 0.05). The AUC of TSH was slightly higher than that of FT4 and gestational age for detecting CH in newborns, but the sensitivity and AUC of combined detection of TSH, FT4 and gestational age were higher than those of single detection of TSH, FT4 and AUC for CH in newborns (P < 0.05). The maternal thyroid abnormality, fetal distress, maternal diabetes, and gestational age < 33 weeks were independent risk factors for CH in newborns (P < 0.05). Conclusion: TSH, FT4 and gestational age have higher predictive value for CH in newborns. The combined detection of TSH, FT4 and gestational age has the highest predictive value, which can be applied as one of the optimal screening schemes for CH in newborns. And the maternal thyroid abnormality, fetal distress, maternal diabetes and gestational age < 33 weeks are independent risk factors for CH in newborns. The occurrence of CH in newborns can be avoided by preventing these factors.