Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

被引：162

作者：

Liu, Qin

Vrontou, Sophia

Rice, Frank L.

Zylka, Mark J.

Dong, Xinzhong

Anderson, David J.

机构：

[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

[3] Howard Hughes Med Inst, Pasadena, CA 91125 USA

[4] Albany Med Coll, Ctr Neuropharmacol & Neurosci, Albany, NY 12208 USA

[5] Univ N Carolina, Ctr Neurosci, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 08期

关键词：

D O I：

10.1038/nn1937

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

C-fiber tactile afferents are a subpopulation of unmyelinated cutaneous sensory neurons activated by gentle stroking. Using a genetically encoded tracer, we found that Mas-related G protein-coupled receptor B4 marks a rare subpopulation of unmyelinated, nonpeptidergic sensory fibers that exclusively innervate hairy skin. These fibers terminate in large arborizations similar in size and distribution to C-fiber tactile afferent receptive fields, suggesting that MrgprB4 may provide genetic access to these elusive neurons in mice.

引用

收藏

页码：946 / 948

页数：3

相关论文

共 15 条

[1] A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons [J].

Dong, XZ ;

Han, SK ;

Zylka, MJ ;

Simon, MI ;

Anderson, DJ .

CELL, 2001, 106 (05) :619-632

[2] Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb [J].

Häbler, HJ ;

Timmermann, L ;

Stegmann, JU ;

Jänig, W .

NEUROSCIENCE, 1999, 89 (04) :1259-1268

[3] Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Gαq/11 pathway [J].

Han, SK ;

Dong, XZ ;

Hwang, JI ;

Zylka, MJ ;

Anderson, DJ ;

Simon, MI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :14740-14745

[4]

KUMAZAWA T, 1977, J PHYSIOLOGY PARIS, V73, P287

[5] Calcitonin gene-related peptide immunoreactivity and afferent receptive properties of dorsal root ganglion neurones in guinea-pigs [J].

Lawson, SN ;

Crepps, B ;

Perl, ER .

JOURNAL OF PHYSIOLOGY-LONDON, 2002, 540 (03) :989-1002

[6] Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs [J].

Lembo, PMC ;

Grazzini, E ;

Groblewski, T ;

O'Donnell, D ;

Roy, MO ;

Zhang, J ;

Hoffert, C ;

Cao, J ;

Schmidt, R ;

Pelletier, M ;

Labarre, M ;

Gosselin, M ;

Fortin, Y ;

Banville, D ;

Shen, SH ;

Ström, P ;

Payza, K ;

Dray, A ;

Walker, P ;

Ahmad, S .

NATURE NEUROSCIENCE, 2002, 5 (03) :201-209

[7] Unmyelinated tactile afferents signal touch and project to insular cortex [J].

Olausson, H ;

Lamarre, Y ;

Backlund, H ;

Morin, C ;

Wallin, BG ;

Starck, G ;

Ekholm, S ;

Strigo, I ;

Worsley, K ;

Vallbo, ÅB ;

Bushnell, MC .

NATURE NEUROSCIENCE, 2002, 5 (09) :900-904

[8] Innervation territories of mechano-insensitive C nociceptors in human skin [J].

Schmidt, R ;

Schmelz, M ;

Weidner, C ;

Handwerker, HO ;

Torebjörk, HE .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (04) :1859-1866

[9] CAPSAICIN-INDUCED ACTIVATION OF FINE AFFERENT-FIBERS FROM RAT SKIN IN-VITRO [J].

SENO, N ;

DRAY, A .

NEUROSCIENCE, 1993, 55 (02) :563-569

[10] CENTRAL PROJECTIONS OF IDENTIFIED, UNMYELINATED (C) AFFERENT-FIBERS INNERVATING MAMMALIAN SKIN [J].

SUGIURA, Y ;

LEE, CL ;

PERL, ER .

SCIENCE, 1986, 234 (4774) :358-361