Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster

被引：21

作者：

Cui, Juan ^{[1
,2
]}

Mao, Xizeng ^{[1
,2
]}

Olman, Victor ^{[1
,2
]}

Hastings, P. J. ^{[3
]}

Xu, Ying ^{[1
,2
,4
]}

机构：

[1] Univ Georgia, Computat Syst Biol Lab, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX USA

[4] Jilin Univ, Coll Comp Sci & Technol, Jilin, Peoples R China

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2012年 / 4卷 / 03期

关键词：

GENE;

D O I：

10.1093/jmcb/mjs017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：174 / 176

页数：3

共 12 条

[1] Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis [J].

DeBerardinis, Ralph J. ;

Mancuso, Anthony ;

Daikhin, Evgueni ;

Nissim, Ilana ;

Yudkoff, Marc ;

Wehrli, Suzanne ;

Thompson, Craig B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19345-19350

[2] Mechanisms of Disease: Hypoxia and Inflammation. [J].

Eltzschig, Holger K. ;

Carmeliet, Peter .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (07) :656-665

[3] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[4] Hypoxia - A key regulatory factor in tumour growth [J].

Harris, AL .

NATURE REVIEWS CANCER, 2002, 2 (01) :38-47

[5] Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation [J].

Heiden, Matthew G. Vander ;

Cantley, Lewis C. ;

Thompson, Craig B. .

SCIENCE, 2009, 324 (5930) :1029-1033

[6] Otto Warburg's contributions to current concepts of cancer metabolism [J].

Koppenol, Willem H. ;

Bounds, Patricia L. ;

Dang, Chi V. .

NATURE REVIEWS CANCER, 2011, 11 (05) :325-337

[7]

Loeb LA, 1998, ADV CANCER RES, V72, P25, DOI 10.1016/S0065-230X(08)60699-5

[8] Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis [J].

Poola, I ;

DeWitty, RL ;

Marshalleck, JJ ;

Bhatnagar, R ;

Abraham, J ;

Leffall, LD .

NATURE MEDICINE, 2005, 11 (05) :481-483

[9]

Singh G, 1999, J CELL PHYSIOL, V180, P431, DOI 10.1002/(SICI)1097-4652(199909)180:3<431::AID-JCP14>3.0.CO

[10]

2-O

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