Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition From Cardiovascular Development to Disease

被引:345
作者
Kovacic, Jason C. [1 ]
Mercader, Nadia [2 ]
Torres, Miguel [2 ]
Boehm, Manfred [3 ]
Fuster, Valentin [1 ,2 ,4 ]
机构
[1] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA
[2] CNIC, Madrid, Spain
[3] NHLBI, Ctr Mol Med, Bethesda, MD 20892 USA
[4] Mt Sinai Sch Med, Marie Josee & Henry R Kravis Cardiovasc Hlth Ctr, New York, NY USA
基金
美国国家卫生研究院;
关键词
endothelium; epithelium; development; endocardium; vasculature; cardiovascular diseases; PLASMINOGEN-ACTIVATOR INHIBITOR-1; TRANSCRIPTION FACTOR SNAIL; EPICARDIUM-DERIVED CELLS; VASCULAR SMOOTH-MUSCLE; THYMOSIN BETA 4; CARDIAC FIBROSIS; IN-VIVO; MYOCARDIAL FIBROSIS; CELLULAR SENESCENCE; EARLY MORPHOGENESIS;
D O I
10.1161/CIRCULATIONAHA.111.040352
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1795 / 1808
页数:14
相关论文
共 160 条
  • [21] Differential Notch Signaling in the Epicardium Is Required for Cardiac Inflow Development and Coronary Vessel Morphogenesis
    del Monte, Gonzalo
    Casanova, Jesus C.
    Antonio Guadix, Juan
    MacGrogan, Donal
    Burch, John B. E.
    Maria Perez-Pomares, Jose
    Luis de la Pompa, Jose
    [J]. CIRCULATION RESEARCH, 2011, 108 (07) : 824 - U137
  • [22] Vascular calcification - Pathobiology of a multifaceted disease
    Demer, Linda L.
    Tintut, Yin
    [J]. CIRCULATION, 2008, 117 (22) : 2938 - 2948
  • [23] Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
    Dettman, RW
    Denetclaw, W
    Ordahl, CP
    Bristow, J
    [J]. DEVELOPMENTAL BIOLOGY, 1998, 193 (02) : 169 - 181
  • [24] Epithelial-mesenchymal transition of epicardial mesothelium is a source of cardiac CD117-positive stem cells in adult human heart
    Di Meglio, Franca
    Castaldo, Clotilde
    Nurzynska, Daria
    Romano, Veronica
    Miraglia, Rita
    Bancone, Ciro
    Langella, Giuseppina
    Vosa, Carlo
    Montagnani, Stefania
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2010, 49 (05) : 719 - 727
  • [25] Vasculogenesis in the day 6.5 to 9.5 mouse embryo
    Drake, CJ
    Fleming, PA
    [J]. BLOOD, 2000, 95 (05) : 1671 - 1679
  • [26] Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
    Duan, Jinzhu
    Gherghe, Costin
    Liu, Dianxin
    Hamlett, Eric
    Srikantha, Luxman
    Rodgers, Laurel
    Regan, Jenna N.
    Rojas, Mauricio
    Willis, Monte
    Leask, Andrew
    Majesky, Mark
    Deb, Arjun
    [J]. EMBO JOURNAL, 2012, 31 (02) : 429 - 442
  • [27] A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression
    Essafi, Abdelkader
    Webb, Anna
    Berry, Rachel L.
    Slight, Joan
    Burn, Sally F.
    Spraggon, Lee
    Velecela, Victor
    Martinez-Estrada, Ofelia M.
    Wiltshire, John H.
    Roberts, Stefan G. E.
    Brownstein, David
    Davies, Jamie A.
    Hastie, Nicholas D.
    Hohenstein, Peter
    [J]. DEVELOPMENTAL CELL, 2011, 21 (03) : 559 - 574
  • [28] PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development
    Feng, Qiuting
    Di, Ruomin
    Tao, Fang
    Chang, Zai
    Lu, Shuangshuang
    Fan, Wenjing
    Shan, Congjia
    Li, Xinli
    Yang, Zhongzhou
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (14) : 3711 - 3721
  • [29] The developing embryonic cardiac outflow tract is highly sensitive to oxidant stress
    Fisher, Steven A.
    [J]. DEVELOPMENTAL DYNAMICS, 2007, 236 (12) : 3496 - 3502
  • [30] Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis
    Flier, Sarah N.
    Tanjore, Harikrishna
    Kokkotou, Efi G.
    Sugimoto, Hikaru
    Zeisberg, Michael
    Kalluri, Raghu
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (26) : 20202 - 20212