Reduction ofStreptococcus mutansby probiotic milk: a multicenter randomized controlled trial

被引：27

作者：

Manmontri, Chanika ^{[1
,2
]}

Nirunsittirat, Areerat ^{[2
,3
]}

Piwat, Supatcharin ^{[4
,5
]}

Wattanarat, Onnida ^{[1
,2
]}

Pahumunto, Nuntiya ^{[4
,6
]}

Makeudom, Anupong ^{[2
]}

Sastraruji, Thanapat ^{[2
]}

Krisanaprakornkit, Suttichai ^{[2
,7
]}

Teanpaisan, Rawee ^{[4
,6
]}

机构：

[1] Chiang Mai Univ, Fac Dent, Dept Orthodont & Pediat Dent, Div Pediat Dent, Chiang Mai 50200, Thailand

[2] Chiang Mai Univ, Fac Dent, Ctr Excellence Oral & Maxillofacial Biol, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Fac Dent, Dept Family & Community Dent, Div Community Dent, Chiang Mai 50200, Thailand

[4] Prince Songkla Univ, Fac Dent, Common Oral Dis & Epidemiol Res Ctr, Hat Yai 90112, Songkhla, Thailand

[5] Prince Songkla Univ, Fac Dent, Dept Prevent Dent, Hat Yai 90112, Songkhla, Thailand

[6] Prince Songkla Univ, Fac Dent, Dept Stomatol, Hat Yai 90112, Songkhla, Thailand

[7] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand

来源：

CLINICAL ORAL INVESTIGATIONS | 2020年 / 24卷 / 07期

关键词：

Lactobacillus paracaseiSD1; Plaque; Preschool children; Probiotics; Saliva; Streptococcus mutans; LACTOBACILLUS-PARACASEI SD1; ORAL LACTOBACILLUS; NYVAD CRITERIA; CARIES; STREPTOCOCCI; RELIABILITY; QUALITY;

D O I：

10.1007/s00784-019-03095-5

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective To investigate the effects of probiotics,Lactobacillus paracaseiSD1, on the quantities ofStreptococcus mutansin saliva and plaque samples of preschool children. Design This randomized trial recruited 487 preschool children from eight childcare centers. Participants were assigned to receive a 6-month course of placebo milk daily (group I), probiotic milk either daily (group II) or three days a week (triweekly, group III). The absolute quantities ofS. mutansand total lactobacilli in the saliva and plaque samples at baseline (T0), after intervention (T6), and 6 months after discontinuation (T12) were assessed by qPCR. Results Of 487 children, 354 completed all follow-up periods. However, only 268 children (3.2 +/- 0.8 years old; groups I = 86, II = 89, and III = 93) provided adequate saliva for qPCR. Whereas the quantities ofS. mutanswere significantly decreased in groups II and III compared to group I in the saliva and plaque samples at T6 and T12, those of total lactobacilli were significantly increased (p< 0.0167). There was no difference in the quantities ofS. mutansor total lactobacilli between groups II and III at any period. Significant changes in the quantities ofS. mutansand total lactobacilli lasted until T12 compared to T0 (p< 0.0167). Conclusions Probiotic administration daily or triweekly reducesS. mutansquantities, whereas it increases total lactobacilli quantities that persists at least 6 months after discontinuation in the saliva and plaque samples of preschool children.

引用

页码：2363 / 2374

页数：12