Unresolved mysteries in the biogenesis of mitochondrial membrane proteins

被引：15
作者：
Dimmer, Kai Stefan [1 ]
Rapaport, Doron [1 ]
机构：
[1] Univ Tubingen, Interfac Inst Biochem, D-72076 Tubingen, Germany
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2012年 / 1818卷 / 04期
关键词：
Mitochondrial import; Membrane protein; Mitochondrial translocase; Protein insertion into mitochondrial membrane; TRANSLOCATION CONTACT SITES; BEEF-HEART MITOCHONDRIA; TAIL-ANCHORED PROTEINS; OUTER-MEMBRANE; SACCHAROMYCES-CEREVISIAE; YEAST MITOCHONDRIA; INNER MEMBRANE; TIM23; COMPLEX; TOM COMPLEX; INSERTION PATHWAY;
D O I：
10.1016/j.bbamem.2011.08.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria are essential eukaryotic organelles that are surrounded by two membranes. Both membranes contain a variety of different integral membrane proteins. After three decades of research on mitochondrial biogenesis five major import complexes with more than 40 subunits altogether were identified and characterized. In the current contribution we want to draw attention to some unexplored issues regarding the integration of mitochondrial membrane proteins and to formulate crucial questions that remain unanswered. This article is part of a Special Issue entitled: Protein Folding in Membranes. (C) 2011 Elsevier B.V. All rights reserved.
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收藏
页码：1085 / 1090
页数：6
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