New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities

被引：53
作者：
Abbas, Samir Y. [1 ]
El-Bayouki, Khairy A. M. [1 ]
Basyouni, Wahid M. [1 ]
Mostafa, Eslam A. [1 ]
机构：
[1] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2018年 / 27卷 / 02期
关键词：
4(3H)-Quinazolinones; Thiosemicarbazones; Pyrazoles; Schiff's bases; Antitumor activity; Antiviral activity; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; BIOLOGICAL EVALUATION; INFLUENZA; ANALOGS; H5N1; AGENTS; ASSAY;
D O I：
10.1007/s00044-017-2083-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3H)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC50 for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H5N1 showed moderate to weak activity compared to Zanamivir reference drug.
引用
收藏
页码：571 / 582
页数：12
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