SARS-CoV-2 antibody dynamics among kidney transplant recipients 3 months after BNT162b2 vaccination: a prospective cohort study

被引：1

作者：

Yelin, Dana ^{[1
]}

Rozen-Zvi, Benaya ^{[2
,3
]}

Yahav, Dafna ^{[3
,4
]}

Ben-Dor, Naomi ^{[2
,3
]}

Steinmetz, Tali ^{[2
,3
]}

Agur, Timna ^{[2
,3
]}

Zingerman, Boris ^{[2
,3
]}

Schneider, Shira ^{[2
,3
]}

Lichtenberg, Shelly ^{[2
,3
]}

Ben-Zvi, Haim ^{[3
,5
]}

Mashraki, Tiki ^{[2
,6
]}

Rahamimov, Ruth ^{[2
,3
,6
]}

机构：

[1] Rabin Med Ctr, COVID Clin, Beilinson Campus, Petah Tiqwa, Israel

[2] Rabin Med Ctr, Dept Nephrol & Hypertens, Beilinson Campus, Petah Tiqwa, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[4] Rabin Med Ctr, Infect Dis Unit, Beilinson Campus, Petah Tiqwa, Israel

[5] Beilinson Med Ctr, Rabin Med Ctr, Clin Microbiol Lab, Petah Tiqwa, Israel

[6] Rabin Med Ctr, Dept Transplantat, Beilinson Campus, Petah Tiqwa, Israel

来源：

CLINICAL KIDNEY JOURNAL | 2022年 / 15卷 / 05期

关键词：

antibodies; COVID-19; immune response; kidney transplant; mRNA vaccine; HUMORAL RESPONSE; DURABILITY; KINETICS;

D O I：

10.1093/ckj/sfac031

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Data regarding immunogenicity of mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines among kidney transplant recipients in the months following vaccination are lacking. We aimed to investigate humoral immune response at 3-4 months post-vaccination among a cohort of kidney transplant recipients, compared with a control group of dialysis patients. Anti-spike antibodies were tested at 1 and 3-4 months after vaccination. Of 259 kidney transplant recipients tested at a median time of 110 days from second vaccine dose, 99 (38%) were seropositive, compared with 83% (101/122) of control patients. Younger age, better renal function and lower immunosuppression levels were associated with seropositivity. A total of 14% (13/94) of participants seropositive at 1 month became seronegative at follow-up and 11% (18/165) became seropositive. The latter were mainly individuals with higher antibody levels at 1 month. Antibody levels at 3-4 months were significantly reduced in both study groups, although the decline was more pronounced in the control group. Kidney transplant recipients present poor antibody response to mRNA SARS-CoV-2 vaccination, with only 38% seropositive at 3-4 months. Nevertheless, the decay in antibody response over time is modest, and some patients may present delayed response, reaching adequate antibody levels at 3-4 months. Low seropositivity rates in this group call for investigating other immunization strategies.

引用

页码：992 / 998

页数：7