Common themes in mechanisms of gene silencing

被引：229
作者：
Moazed, D [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
来源：
MOLECULAR CELL | 2001年 / 8卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S1097-2765(01)00340-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The assembly of DNA into regions of inaccessible chromatin, called silent chromatin, is involved in the regulation of gene expression and maintenance of chromosome stability in eukaryotes. Recent studies on Sir2-containing silencing complexes in budding yeast and HP1- and Swi6-containing silencing complexes in metazoans and fission yeast suggest a common mechanism for the assembly of these domains, which involves the physical coupling of histone modifying enzymes to histone binding proteins.
引用
收藏
页码：489 / 498
页数：10
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