Protective Effect of Salvia miltiorrhiza Extract Against Renal Ischemia-Reperfusion-Induced Injury in Rats

被引：32

作者：

Chen, Gang ^{[1
]}

Fu, Yunrui ^{[1
]}

Wu, Xiaohou ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, Chongqing 400016, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 02期

关键词：

Salvia miltiorrhiza ethanol extracts; ischemia reperfusion; Scr; BUN; antioxidant; WEIBEL-PALADE BODIES; SUPEROXIDE-DISMUTASE; FREE-RADICALS; ISCHEMIA/REPERFUSION INJURY; GLUTATHIONE-PEROXIDASE; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; TISSUE-INJURY; FAILURE; KIDNEY;

D O I：

10.3390/molecules17021191

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study investigates the effect of pre-treatment with Salvia miltiorrhiza ethanol extracts (SMEE) on renal function markers, immunity and antioxidant activities in renal ischemia and reperfusion (IR) rats. Wistar rat kidneys were subjected to 60 min of global ischemia at 37 degrees C followed by 30 min of reperfusion, and were randomly assigned into the sham, IR model and three SMEE-treated groups (n = 8 per group). Results showed that high serum creatinin (Scr), blood urea nitrogen (BUN), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) and malondialhehyde (MDA) levels, and low antioxidant enzyme activities were observed in IR rats compared to the sham rats. Pre-treatment of Salvia miltiorrhiza ethanol extracts for 20 days prior to IR operation improved renal function, reduced IR induced renal inflammatory and oxidative injury. It is concluded that Salvia miltiorrhiza ethanol extracts could be beneficial in the treatment of renal ischemic injury.

引用

页码：1191 / 1202

页数：12

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